维持性血液透析患者冠心病事件与丙型肝炎病毒感染的相关性

目的探讨丙型肝炎病毒(hepatitis C virus,HCV)感染与维持性血液透析患者(maintenance hemodialysis,MHD)冠心病(coronary artery disease,CAD)事件的相关性。方法横断面调查分析2011年7月广东省人民医院血液净化中心所有MHD患者的感染控制筛查结果,按HCV阳性和HCV阴性分组,比较两组间CAD的患病率并作多因素logistic回归分析。结果 377例MHD患者中,HCV阳性率为9.0%,CAD患病率为23.9%;HCV阳性组CAD患病率为41.2%,明显高于HCV阴性组(22.8%,P=0.013)。Logistic相关分析显示,MHD患者CAD的发生与HCV感染无关,而年龄、血红蛋白及低密度脂蛋白水平是MHD患者发生CAD的独立危险因素。结论 HCV感染并非MHD患者CAD事件的危险因素,HCV能否预测MHD患者的CAD事件需要前瞻性研究来证实。

Association between hepatitis C virus infection and coronary artery disease in maintenance hemodialysis patients

Objective To investigate the association between hepatitis C virus (HCV) infection and coronary artery disease (CAD) in maintenance hemodialysis (MHD) patients. Methods A cross-sectional survey in MHD patients according to the infection control screening data was conducted in Guangdong General Hospital in July 2011. Patients were divided into two groups (HCV positive group, and HCV negative group). The prevalence of CAD was compared between the two groups, and logistic regression analysis was used to determined the independent risk factors. Results Among 377 MHD patients, HCV positive patients accounted for 9.0% patients, and the prevalence of CAD was 23.9%. The prevalence of CAD was 41.2% in HCV positive group, whereas 22.8% in HCV negative group (P=0.013). Logistic regression analysis showed that age, hemoglobin and low density lipoprotein were associated with increased risk of CAD, indicating that HCV infection was not an independent risk factor for CAD. Conclusion Our study did not demonstrate HCV infection as a risk factor for CAD. Whether HCV infection predicts CAD needs more prospective evidences.