| 飞行人员代谢综合征患者脂联素基因+45和+276位点单核苷酸多态性研究 |
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| 引用本文： | 蔡庆,刘红巾,陈涛,朱美财.飞行人员代谢综合征患者脂联素基因+45和+276位点单核苷酸多态性研究[J].临床军医杂志,2010,38(5). |
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| 作者姓名： | 蔡庆 刘红巾 陈涛 朱美财 |
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| 作者单位： | 解放军空军总医院,临床检验中心,北京,100142 |
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| 基金项目： | "十一五"全军医药卫生科研计划课题，空军"十一五"后勤科研计划空后医学领域项目 |
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| 摘 要： | 目的研究脂联素基因+45和+276位点单核苷酸多态性(SNP)与飞行人员代谢综合征(MS)的相关性。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测38名飞行人员MS患者和50名正常健康飞行人员脂联素基因+45和+276位点SNP。结果 脂联素基因SNP+45和+276基因型和等位基因在飞行人员MS组和正常健康对照组差异无统计学意义。结论脂联素基因SNP+45和+276可能与飞行人员MS无相关性。
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| 关 键 词： | 飞行人员 代谢综合征 脂联素基因 单核苷酸多态性 |
Mononucleotide polymorphism at+45 and+276 site of adiponectin gene in aircrew with metaboilc syndrome |
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| Cai Qing,Liu Hong-jin,Chen Tao,Zhu Mei-cai.Mononucleotide polymorphism at+45 and+276 site of adiponectin gene in aircrew with metaboilc syndrome[J].Clinical Journal of Medical Officer,2010,38(5). |
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| Authors: | Cai Qing Liu Hong-jin Chen Tao Zhu Mei-cai |
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| Abstract: | Objective To study the relationship between single nucleotide polymorphism(SNP) at +45 and +276 site of adiponectin gene and metaboilc syndrome(MS) in aircrews.Methods SNP+45 and SNP+276 of adiponectin gene were assayed in 38 aircrews with MS and 50 healthy controls by polymerase chain reaction-restricted fragmenets length polymorphism(PCR-RFLP).Results The distribution of genotypes and alleles frequence of the SNP+45 and SNP+276 was not statistically different between the aircrews with MS and the healthy controls.Conclusion SNP+45 and SNP+276 of adiponectin gene may be not associated with MS in aircrews. |
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| Keywords: | aircrew metaboilc syndrome adiponectin gene single nucleotide polymorphism |
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