维持性血液透析患者血清白细胞介素-17与贫血关系探讨

目的 观察维持性血液透析患者血清白细胞介素(IL)-17的变化及与贫血的相关性.方法 选择68例遵从K/DOQI指南给予贫血治疗8周未达到预期目标的维持性血液透析患者,根据血红蛋白值分为重度贫血组(12例)、中度贫血组(18例)、轻度贫血组(18例)、无贫血组(20例),血液透析前检测血常规、IL- 17、IL-6、C反应蛋白(CRP)、铁蛋白、转铁蛋白饱和度.对照组(20例)为健康体检者.结果 血液透析贫血各组较对照组血清IL-17、IL-6、CRP水平升高;中、重度贫血组血清IL-17水平较轻度贫血组升高;血清IL-17水平与贫血程度呈正相关.结论 维持性血液透析并贫血患者血清IL-17、IL-6、CRP水平升高,存在微炎性反应状态;IL-17可能作为炎性反应因素参与贫血发生机制的早期检测指标.

Exploration of interleukin-17 amount and its correlation with anemia in the patients with maintenance hemodialysis

Objective To observe the changes of intedeukin (IL)-17 in patients with maintenance hemodialysis (MHD) and its relationship with anemia. Methods Twenty sera from normal people(normal group) and sixty-eight sera from patients with MHD were sampled. Patients with MHD were divided into 4 groups by haemoglobin (Hb) levels: severity anemia group (12 cases), midrange anemia group(18 cases),light anemia group(18 cases) and non-anemia group(20 cases). IL-6 and IL-17 levels were measured in all the sera with ELISA. Meantime, C-reactive protein (CRP),Hb, ferritin and iron saturation ratio was observed. Results CRP,IL-17 and IL-6 levels in MHD patients were much higher than those in normal group. IL-17 levels in severity and midrange anemia group were higher than those in light anemia group,and IL-17 was positively correlated to Hb. Conclusions IL-17,IL-6 and CRP in patients is higher than that in normal people,and the microinflammation status exists in MHD. IL-17 may play a role in pathogenesis of microinflammation in MHD patients with anemia.