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Possible impact of HLA class I and class II on malignancies driven by a single germ-line BRCA1 mutation |
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| Authors: | Milena Ivanova Anastasia Ormandjieva Rumyana Dodova Radka Kaneva Velizar Shivarov |
| Affiliation: | 1. Department of Clinical Immunology, University Hospital Alexandrovska, Medical University Sofia, Sofia, Bulgaria;2. Center for Molecular Medicine, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University Sofia, Sofia, Bulgaria;3. Department of Experimental Research, Medical University Pleven, Pleven, Bulgaria |
| Abstract: | This study provides the first immunogenetic preliminary evidence that specific human leucocyte antigen (HLA) class I and class II alleles and haplotypes may be relevant for BRCA1 c.5263_5264insC driven oncogenesis. Observed HLA associations might have practical implications for establishment of predictive markers for the response to immunotherapies in malignancies driven by this germ-line mutation. |
| Keywords: | BCRA1 mutation breast cancer HLA class I HLA class II ovarian cancer |