| 莫索尼定及贝那普利对肾组织细胞外基质调节因子影响的研究 |
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| 引用本文： | 邹春波,解汝娟,隋满姝,穆素红,李丽.莫索尼定及贝那普利对肾组织细胞外基质调节因子影响的研究[J].中国血液净化,2009,8(1). |
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| 作者姓名： | 邹春波 解汝娟 隋满姝 穆素红 李丽 |
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| 作者单位： | 哈尔滨医科大学附属第一医院肾内科,哈尔滨,150001 |
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| 摘 要： | 目的应用交感神经抑制剂莫索尼定及贝那普利干预阿霉素肾病大鼠,比较二者对肾组织细胞外基质及其调节因子基质金属蛋白酶-9(MMP-9)、基质金属蛋白组织抑制因子-1(TIMP-1)的影响。方法大鼠右肾摘除加尾静脉注射阿霉素,随机分为模型组、莫索尼定组、贝那普利组、对照组。12周测血、尿生化指标及血压;光镜及电镜观察肾组织形态学改变;免疫组化检测肾组织MMP-9、TIMP-1蛋白表达;原位杂交测MMP-9mRNA、TIMP-1mRNA表达。结果与对照组比较,模型组大鼠蛋白尿、血浆NE、AngⅡ水平、血压、肾损害指标均上升;肾组织内MMP-9、TIMP-1蛋白及mRNA表达均明显上调;两治疗组与模型组比较,MMP-9蛋白及mRNA进一步上调,生化指标及TIMP-1都被显著抑制。贝那普利较莫索尼定更明显降低蛋白尿及血浆AngⅡ水平。结论莫索尼定及贝那普利均具有肾保护作用,部分机制可能是通过抑制交感神经活性,调节细胞外基质降解而起作用。
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| 关 键 词： | 莫索尼定 贝那普利 细胞外基质 基质金属蛋白酶-9 基质金属蛋白酶组织抑制因子-1 |
A comparison study about the effect of Moxonidine and Benazepril on extracellular maxtrix regulatory factors in rat kidney |
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| ZOU Chun-bo,XIE Ru-juan,SUI Man-shu,MU Su-hong,LI Li.A comparison study about the effect of Moxonidine and Benazepril on extracellular maxtrix regulatory factors in rat kidney[J].Chinese Journal of Blood Purification,2009,8(1). |
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| Authors: | ZOU Chun-bo XIE Ru-juan SUI Man-shu MU Su-hong LI Li |
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| Institution: | ZOU Chun-bo; XIE Ru-juan; SUI Man-shu; MU Su-hong; LI Li Division of Nephrology; The First Affiliated Hospital of Harbin Medical University; Harbin 150001; China; |
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| Abstract: | Objective To compare the effects of Moxonidine and Benazepril on the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in kidney of Adriamycin-treated rats. Method Uninephrectomized Wistar rats were given intravenously Adriamycin and then divided into model group,Moxonidine group (1.5mg/kg),Benazepril group (10mg/kg) and control group. By the end of the 12th week,blood pressure,proteinuria,plasma norepinephrine (NE) and plasma angiotensin Ⅱ (Ang Ⅱ) were me... |
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| Keywords: | Moxonidine Benazepril MMP-9 TIMP-1 |
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