注射用泮托拉唑钠治疗非曲张静脉上消化道出血疗效观察

目的　评价泮托拉唑钠治疗非曲张静脉上消化道出血的疗效和安全性 ,并与雷尼替丁做对照。方法　选择上消化道出血患者 70例 ,随机分泮托拉唑钠组 35例 ,其中胃溃疡并出血 14例 ,十二指肠球部溃疡并出血 17例 ,急性糜烂出血性胃炎 3例 ,胃癌 1例 ;雷尼替丁组 35例 ,其中胃溃疡并出血 15例 ,十二指肠球部溃疡并出血 15例 ,急性糜烂出血性胃炎 4例 ,胃癌 1例。方法 :分别用泮托拉唑钠 80mg或雷尼替丁 15 0mg加入 5 %葡萄糖液 2 5 0ml内静脉点滴 (30～ 6 0min) 1次 /d ,共 5d ,观察生命体征和出血情况的变化。结果　两组出血情况差异无显著性 (P >0 .0 5 )。治疗后 3d内泮托拉唑钠组有 2 8例止血 ,4～ 5d内止血有 6例 ,5d以上未止血者 1例 ,止血总有效率为 94 .36 % ;3d内雷尼替丁组有 2 5例止血 ,4～ 5d内有 5例止血 ,5d以上未止血者 5例 ,止血总有效率为 :85 .71%。治疗后两组总有效率比较有显著差异 (P <0 .0 1)。泮托拉唑钠组无不良反应 ,雷尼替丁组有 1例出现恶心症状 ,不良反应发生率为 2 .85 %。结论　注射用泮托拉唑钠是治疗非曲张静脉上消化道出血安全、有效的药物。

The Effects of Pantoprazole on Patients with Non-varices Upper Gastrointestinal Bleeding

Objective To evaluate the effects of pantoprazole on patients with non-varices upper gastrointestinal bleeding and its safety,as compared with Ranitidine.Methods Seventy patients with non-varices upper gastrointestinal bleeding were randomly assigned to two groups.Thiret-five patients were in the group of pantoprazole, including 14 patients with gastriculcer,17 duodenal ulcer and 3 erosive gastritis,1 gastric cancer;35 patients were in the group of Ranitidine including 15 patients with gastric ulcer,15 duodenal ulcer and 4 erosive gastritis,1 gastric cancer.Treatment schemes: either pantoprazole 80mg or Ranitidine 150 mg was added into 250 ml 5% glucose respectively and then infused intravenously.The course of therapy was 5 days.The clinical signs of the patients including the amout of bleeding were observed.Results After the treatment the total effective rate in pantoprazole group and Ranitidine group were 94.36% and 85.71%.The differences were significant statistically between pantoprazole group and Ranitidine group(P<0.01).The rates of side effects were 0% in Pantoprazole group and 2.85% in Ranitidine group.Conclusion Pantoprazole is and effective and safe drug for the non-varices upper gastrointestinal bleedingas compared with Ranitidine.