负压创面疗法治疗原理与研究进展

负压创面疗法（negative pressure wound therapy,NPWT）广泛用于各种难愈性创面的治疗。其主要作用机制为增加伤口血流灌注,减轻组织水肿,抑制细菌生长防止交叉感染,促进修复细胞的增殖同抑制凋亡。随着治疗适应证的增加,一些新的问题有待进一步研究,如最适负压值,敷料更换时间,合理的治疗时间等。本文对负压创面疗法的作用机制和现阶段需要解决的问题做一综述。

The research progress and theory of negative pressure wound therapy

Negative pressure wound therapy is widely applied to all kinds of refractory wound. Its primary mechanism of action is increasing wound perfusion, loss of tissues edema, inhibition of bacterial growth and preventing cross infection, to promote the repair of cell proliferation and apoptosis. As the increase of indications, some new problems need to be studied. Such as the optimum negative pressure vale,period of replacing accessories, the optimum therapeutic time. This paper will be reviewed based on mechanism negative pressure wound therapy and the problems need to be solved.