PCT与CRP联合检测对新生儿败血症的诊断价值

目的探讨新生儿败血症应用血浆降钙素原(PCT)及C反应蛋白(CRP)联合检测的诊断价值。方法入选我院2011年1月至2014年1月新生儿败血症患儿80例为观察组,入选同期体检健康新生儿80例作为对照组。分别应用免疫层析法和免疫散射法检测两组的血浆降钙素原(PCT)及C反应蛋白(CRP),比较两组的PCT、CRP指标水平,比较两项检测指标的阳性预测值、特异性、灵敏度。结果观察组的C反应蛋白及降钙素原等检测指标显著高于对照组,差异具有统计学意义(P<0.05);PCT与CRP检测指标的灵敏度、阳性预测值比较,结果无统计学意义(P>0.05);PCT与CRP的特异性比较,结果具有统计学意义(P<0.05)。结论血浆降钙素原及C反应蛋白为新生儿败血症的敏感检测指标,对早期诊断新生儿败血症具有重要的临床意义。

Clinical Value of PCT Combined with CRP in the Diagnosis of Neonatal Septicemia

Objective To explore diagnostic value of procalcitonin （PCT） and C reactive protein （CRP） for neonatal septicemia. Methods From January 2011 to January 2014, 80 cases of neonatal septicemia and 80 cases of healthy neonate in our hospital were selected as the observation group and the control group respectively. The PCT and CRP levels were detected by immunochromatographic method and immuno-scatter turbidmetry respectively, and and compared between two groups. The positive predictive value, specificity and sensitivity of PCT and CRP were compared. Results The CRP level and PCT level of observation group were significantly higher than those of control group （P〈0.05）. There were no statistical differences in the sensitivity, positive predictive value between CRP and PCT （P〉0.05）, but there was statistical difference in the specificity between CRP and PCT （P〈0.05）. Conclusions Both PCT and CRP are the sensitive detection indices for neonatal septicemia, and have important significance for the diagnosis of neonatal septicemia.