原发性肝癌患者手术前后血清SICAM-1、L-Selection和VEGF检测的临床意义

目的：探讨原发性肝癌患者手术前后血清可溶性细胞间黏附分子-1（SICAM-1）、L-选择素（L—Selection）和血管内皮生长因子（VEGF）水平的变化。方法：采用双抗体夹心法（ELISA）对35例原发性肝癌患者进行手术前后血清SICAM-1、L—Selection和VEGF测定，并与30名正常健康人作比较。结果：手术前血清SICAM-1、L—Selection和VEGF水平非常显著地高于正常人组（P〈0．01）。手术后6个月，复发者血清SICAM-1、L-Selection和VEGF水平持续异常；未复发者SICAM-1、L—Selection和VEGF水平恢复正常。结论：观察原发性肝癌患者血清SICAM-1、L—Selection和VEGF水平的变化与原发性肝癌患者的病情和预后密切相关．

Clinical Significance of Measurements of Changes of Serum SICAM-1, L-Selection and VEGF Levels After Operative Treatment in Patients with Primary Liver Cancer

Objective To study the changes of the serum SICAM-1,L-Selection and VEGF levels after operative treatment in 35 patients with primary liver cancers.Methods Serum SICAM-1,L-Selection and VEGF(with ELISA)levels were measured in 35 patients with primary liver cancers both before and after operative treatment as well as in 30 controls.Results Before operation,the serum SICAM-1,L-Selection and VEGF levels in the patients were significantly higher than those in the controls(P<0.01).Six months after operation,patients without recurrence had their SICAM-1,L-Selection and VEGF levels returned to normal but in the patients with recurrences the levels were about the same as those before operation.Conclusion The changes of serum SICAM-1,L-Selection and VEGF levels in patients with liver cancers were closely related to the progress of diseases and could be of prognostic value.