西吡氯铵体外抑菌实验研究

目的研究西吡氯胺对牙周相关致病菌的抑制作用。方法选用牙周主要致病菌的国际参考菌株，牙龈卟啉单胞菌、中间普氏菌、粘性放线菌和具核梭杆菌，以氯己定作为对照，采用杯碟法进行抑菌实验，观察最小抑菌浓度和测量抑菌环直径大小，评价西吡氯胺含漱液对受试细菌的抑菌作用。结果西吡氯胺对4个菌种的抑菌作用明显，与对照组氯己定比较，最小抑菌浓度差异无统计学意义；0．1％西吡氯胺含漱液与0．1％氯己定含漱液的抑菌效果无显著差异。结论0．1％西吡氯胺含漱液对牙周相关致病菌的抑制作用与氯己定含漱液作用相同。

Inhibitory effect of cetylpyridinium chloride on bacteria in vitro

Objective To test the antibacterial effect of cetylpyridinium chloride on four periodontal pathogens. Methods Porphyromonas gingivalis （ P. g ATCC33277 ）, Prevotella intermedia （ P. i ATCC25611 ）, Actinnomyces viscosus（A, v ATCC19246 ）and Fusobacterium nucleatum（ F. n ATCC10953 ） were selected. Argrose diffusion test was used and chlorhexidine served as control. The inhibitory effects of cetylpyridinium chloride were examined by testing minimal inhibitory concentration （ MIC ） and the diameter of inhibitory zone. Results The cetylpyridinium chloride ＂s inhibitory effect on the four bacterial strains was remarkable, but the difference in the inhibitory effects was not significant between cetylpyridinium chloride and chlorhexidine. Conclusion Cetylpyridinium chloride had same inhibitory effect on the four bacterial strains tested as chlorhexidine.