| 大鼠肾缺血/再灌注损伤不同时相Fas、FasL蛋白表达及意义 |
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| 引用本文： | 于新路,王禾,张波,张更,武国军,刘贺亮. 大鼠肾缺血/再灌注损伤不同时相Fas、FasL蛋白表达及意义[J]. 中国组织工程研究与临床康复, 2003, 7(2): 350-351 |
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| 作者姓名： | 于新路 王禾 张波 张更 武国军 刘贺亮 |
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| 作者单位： | Department of Urology，Xijing Hospital，Fourth Hilitarjr Medical University，Department of Urology，Xijing Hospital，Fourth Hilitarjr Medical University，Department of Urology，Xijing Hospital，Fourth Hilitarjr Medical University，Department of Urology，Xijing Hospital，Fourth Hilitarjr Medical University，Department of Urology，Xijing Hospital，Fourth Hilitarjr Medical University，Department of Urology，Xijing Hospital，Fourth Hilitarjr Medical University Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China |
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| 摘 要： | AIM: To study the relationship between the expression of Fas/FasL protein and apoptosis in rats after renal ischemia/repernision. METHODS: Establish the models of renal ischemia/reperfusion injury in rat and SABC im-munohistochemical methods were used to detect the changes of expression of Fas/FasL protein. Pathomorphological changes in renal ischemia/reperfusion injury were observed. RESULTS: The expression of Fas/FasL proteins was negative in the sham operated group. Fas/FasL proteins were increased in renal in ischemia/reperfusion group, and gradually upregulated with the duration of ischemia or reperfusion and peaked at 72 h of reperfusion. The expression of Fas/FasL proteins was atronger in 60 min ischemia group than 30 min ischemia group and they were mainly expressed in renal tubule. We observed local necrosis and inflammatory cells infiltration around infracted area in ischemia/repernision group by HE dyeing methods. And the necrosis area was mainly occurred around proximal convoluted tubule. CO
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Changes of expression of Fas and FasL protein in rats after renal ischemia/reperfusion injury |
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| Yu Xinlu,Wang He,Zhang Bo,Zhang Geng. Wu Guojun,Liu He-liang. Changes of expression of Fas and FasL protein in rats after renal ischemia/reperfusion injury[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(2): 350-351 |
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| Authors: | Yu Xinlu Wang He Zhang Bo Zhang Geng. Wu Guojun Liu He-liang |
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| Affiliation: | Department of Urology, Xijing Hospital,Fourth Military Medical University,Xi′ an 710032,Shaanxi Province,China |
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| Abstract: | AIM: To study the relationship between the expression of Fas/FasL protein and apoptosis in rats after renal ischemia/repernision. METHODS: Establish the models of renal ischemia/reperfusion injury in rat and SABC im-munohistochemical methods were used to detect the changes of expression of Fas/FasL protein. Pathomorphological changes in renal ischemia/reperfusion injury were observed. RESULTS: The expression of Fas/FasL proteins was negative in the sham operated group. Fas/FasL proteins were increased in renal in ischemia/reperfusion group, and gradually upregulated with the duration of ischemia or reperfusion and peaked at 72 h of reperfusion. The expression of Fas/FasL proteins was atronger in 60 min ischemia group than 30 min ischemia group and they were mainly expressed in renal tubule. We observed local necrosis and inflammatory cells infiltration around infracted area in ischemia/repernision group by HE dyeing methods. And the necrosis area was mainly occurred around proximal convoluted tubule. CONCLUSIONS: These findings suggested that Fas/FasL proteins were over expressed after ischemia/reperrusion injury in rats renal. And Fas/FasL system was involved in the process of renal ischemia/repernision injury. |
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| Keywords: | ischemia/reperfusion Fas/FasL protein apoptosis |
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