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Production of IgA monoclonal antibodies against influenza A virus |
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| Authors: | M L Wang |
| Affiliation: | 1. Laboratory for Financial Engineering, Sloan School of Management, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States;2. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States;3. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States;4. Sante Fe Institute, Santa Fe, New Mexico, United States |
| Abstract: | Nineteen IgA monoclonal antibodies against influenza A virus X-31 were obtained following intranasal infection of mice with influenza A virus X-31. It was demonstrated that specificities of IgA monoclonal antibodies are similar to those of IgG monoclonal antibodies. These IgA antibodies might be useful for the study of mucosal immunity against influenza A viruses. Infection may be an easier and better way of producing monoclonal antibodies against some viral agents. |
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