马吲哚与芬氟拉明治疗单纯性肥胖的比较

目的：比较马吲哚与芬氟拉明对单纯性肥胖的疗效。方法：单纯性肥胖２６０例，随机分为２组，马吲哚组１３０例（男性４５例，女性８５例；年龄４１±ｓ９ａ）用马吲哚１ｍｇｐｏ，ｂｉｄ；芬氟拉明组１３０例（男性４９例，女性８１例；年龄４３±１１ａ）用芬氟拉明２０ｍｇ，ｐｏ，ｔｉｄ。２组治疗均８ｗｋ。结果：马吲哚组体重下降５．２±２．０ｋｇ，有效率为８２．３％，芬氟拉明组下降４．７±１．８ｋｇ，有效率为７３．１％；２组均有总胆固醇、舒张压、胰岛素及生长激素降低及超氧化物歧化酶－铜－锌升高，其程度马吲哚组优于芬氟拉明组（Ｐ均＜０．０１）。马吲哚组尚能克服嗜睡，对胃肠道不良反应少。结论：马吲哚可作为一种有效的减肥药。

Mazindol vs fenfluramine in treating simple obesity

AIM:To compare mazindol(Maz)with fenfluramine(Fen)in treating simple obesity.METHODS:simple obese patients were randomly divided into 2 groups,Maz group and Fen group,each contained 130 patients. Maz group(M 45,F85,age 41±s 9 a)treated with Maz 1 mg,po,bid, and Fen group(M 49,F 81,age 43±11 a) with Fen 20 mg,po,tid,all for 8 wk.RESULTS:Average body weight loss and effective rate in Maz group were 5.2±2.0kg and 82.3% respectively,while in Fen group were 4.7±1.8 kg and 73.1%respectively.The effects of Maz on depressing diastole blcod pressure,reducing total cholesterol,insulin and growth hormone,and increasing SOD-Cu-Zn were better than those Fen group(P<0.01).In addition Maz could shorten sleep time,and the adverse reactions related to gastrointestinal tract were significantly lower than that in Fen group.CONCLUSION:Maz is a drug of choice in treating obsity.(Changzhou First People' s Hospital,Changzhou 213003)(Affiliated Hospital of Yangzhou Medical College,Yangzhou 225000)(Nanjing Medical College,Nanjing 210004)(Liyang Pharmaceutical Factory, Liyang 213300)