非糖尿病血液透析患者颈总动脉僵硬度及相关因素

目的评价非糖尿病血液透析患者颈总动脉僵硬度,探讨可能影响颈总动脉僵硬度的危险因素。方法采用超声Echo-tracking技术测定80例非糖尿病血液透析患者的颈总动脉可扩张性系数(distensibility coefficient,DC),作为评价颈总动脉僵硬度的指标,常规检测白蛋白、总胆固醇、高密度脂蛋白、低密度脂蛋白、三酰甘油、血糖、肌酐、钙、磷、甲状旁腺素、超敏C反应蛋白。结果颈总动脉DC为(14.47±5.19)(10-3/kPa),多元逐步回归分析显示收缩压(β=-0.340,P<0.01)、年龄(β=-0.248,P<0.05)、血钙(β=-0.199,P<0.05)与颈总动脉DC独立相关。结论收缩压、年龄及血钙升高是非糖尿病血液透析患者颈总动脉僵硬度增加的独立危险因素。

Determinants of Arterial Distensibility in Non-diabetic Hemodialysis Patients

Objective To evaluate the arterial stiffness in non-diabetic hemodialysis patients and to investigate the risk factors for arterial stiffness. Methods A total of 80 non-diabetic hemodialysis patients were recruited. The distensibility coefficient(DC) of the common carotid artery was evaluated by an ultrasonic phase-locked echo-tracking system. Serum albumin, total cholesterol(TC), high density lipoprotein(HDL), low density lipoprotein(LDL), triglyceride(TG), glucose, creatinine, high sensitive C-reactive protein(hs-CRP), calcium, phosphorus, and intact parathyroid hormone(iPTH) were determined with standard methods. Results Carotid DC was(14.47±5.19)(10^-3/kPa) in the non-diabetic hemodialysis patients studied. In stepwise multiple regression analysis, systolic blood pressure(β=-0.340, P<0.01), age(β=-0.248, P<0.05), and serum calcium(β=-0.199, P<0.05) were independently correlated with carotid DC. Conclusion Systolic blood pressure, age, and serum calcium were independent determinants for carotid arterial stiffness in non-diabetic hemodialysis patients.