抗角蛋白抗体在类风湿性关节炎早期诊断中的价值

目的：评价抗角蛋白抗体（AKA）、类风湿因子（RF）和抗环瓜氨酸肽（CCP）在类风湿性关节炎（RA）诊断中的价值。方法：收集2011年1月～2012年1月在我院就诊的类风湿性关节炎患者85例和135例健康人血清,采用间接荧光法检测AKA,采用散射比浊法检测RF,使用化学发光检测抗CCP抗体,分析三者之间的相关性。结果：抗CCP抗体、AKA、RF敏感性分别为0.84、0.58、0.73,特异性分别为0.96、0.89、0.91,阳性预测值分别为0.93、0.77、0.84。结论：抗CCP抗体敏感度和特异度均优于AKA、RF,AKA作为一个新的诊断指标与抗CCP抗体、RF有一定的相关性,临床上应合理地选择检测项目,提高RA的诊断率。

The Value of Anti-keratin Antibodies in the Early Diagnosis of Rheumatoid Arthritis

Objective：To evaluate the value of antikeratin antibodies （AKA）, rheumatoid factor （RF）and anti-cyclic citrallinated peptide （CCP）in the diagnosis of rheumatoid arthritis （RA）,which have been shown to be diagnostic makers of RA. Methods： To analyze the relationship between these three makers, 85 cases of patients with RA and 135 healthy human were enrolled in our hospital from January 2011 to January 2012. The content of AKA were detected by IIF when anti-CCP antibodies were detected by CLIA and RF were detemlined by scattering turbidimetty. Results： The sensitivity of anti-CCP antibodies, AKA and RF were 0.84,0.58 and 0.73 respectively. And the specificity of these were 0.96, 0.89 and 0.91 in turn, of which the positive predictive value were 0.93, 0.77 and 0.84. Conclusion： Anti-CCP antibodies showed the highest specificity and sensitivity when compared to RF and AKA. A8 a new diagnostic marker for RA, AKA have relation to anti-CCP antibodies and RF. We should choose the suitable item to enhance the diagnostic rate of RA.