壮骨活血方预防骨质疏松性股骨颈骨折患者股骨头坏死的疗效观察

目的:观察壮骨活血方预防骨质疏松性股骨颈骨折患者股骨头坏死的疗效。方法:将305例骨质疏松性股骨颈骨折患者随机分成治疗组和对照组。在对2组患者实施内固定手术和皮肤持续牵引治疗的同时,治疗组给予口服壮骨活血方(煎剂,每日2次)12周;对照组给予骨肽和葛根素治疗。2组分别于术后第1、2、4、6、12、18个月拍摄股骨颈正侧位X线片,观察骨折愈合及股骨头坏死发生情况;术后第4、6、8个月查双髋关节核磁共振成像观察有无侧股骨头坏死发生。结果:治疗组股骨头坏死率、骨折不愈合率均显著低于对照组(P<0.01)。结论:在治疗骨质疏松性股骨颈骨折中,壮骨活血方有助于降低股骨头坏死发生率,从而达到预防股骨头坏死的临床疗效。

Efficacy Observation of Zhuanggu Huoxue Recipe for Necrosis of Femoral Head in Patients with Osteoporotic Femoral Neck Fracture

OBJECTIVE：To investigate the clinical efficacy of Zhuanggu huoxue recipe for necrosis of femoral head in patients with osteoporotic femoral neck fracture. METHODS：305 patients with osteoporotic femoral neck fracture randomized into therapy group and control group. Both groups were given internal fixation therapy and continuous traction treatment for skin. Therapy group were given Zhuanggu huoxue decoction （p.o. b.i.d） for 12 weeks. Control group were given ossotide and puerarin. At 1st month,2nd month,4th month,6th month,12th month,18th month after operation,roentgenograms of bone in femoral lateral position were taken to observe the fracture healing and the occurrence of femoral head necrosis. At 4th month,6th month,8th month after radiotherapy,MRI of double lateral hip was taken to observe the occurrence of femoral head necrosis. RESULTS：The rate of femoral head necrosis and nonunion of fracture in therapy group were all lower than in control group （P〈0.01）.CONCLUSION：Zhuanggu huoxue recipe contribute to prevent femoral head necrosis through reducing incidence of femoral head necrosis.