氨氯地平联合阿托伐他汀治疗原发性高血压的疗效观察

目的:观察氨氯地平联合阿托伐他汀治疗原发性高血压的临床疗效。方法:104例原发性高血压患者随机分为2组,每组52例。观察组采用氨氯地平联合阿托伐他汀治疗,对照组仅采用氨氯地平治疗,观察比较2组的临床疗效及对血脂、血压、脉压的影响。结果:观察组的总有效率(92.3%)明显高于对照组(76.9%),2组比较差异有统计学意义(P<0.05)。观察组治疗后总胆固醇、甘油三酯水平均明显低于同期对照组(P<0.05),观察组与治疗前比较差异有统计学意义。2组治疗后收缩压、舒张压及脉压明显下降,与治疗前比较差异均有统计学意义(P<0.05);并且,观察组治疗后收缩压、舒张压及脉压均明显低于同期对照组,2组比较差异有统计学意义(P<0.05)。结论:在氨氯地平基础上加用阿托伐他汀能够明显提高治疗原发性高血压的临床疗效,降低患者血脂水平,且降低血压和脉压效果更为明显,二者联合应用具有良好的协同作用。

Clinical Observation on Amlodipine Combined with Atorvastatin in the Treatment of Primary Hypertension

OBJECTIVE： To observe the clinical efficacy of amlodipine combined with atorvastatin in the treatment of primary hypertension. METHODS： 104 patients with primary hypertension were randomly divided into two groups （n=52）. Observation group were treated with amlodipine combined with atorvastatin and control group were given amlodipine alone. Clinical efficacies, blood pressure and pulse pressure were observed and compared between two groups. RESULTS： The total effective rate（92.3% ） in observation group was significantly higher than control group （76.9%）. There were statistical significance in difference between two groups（P〈0.05）. After treatment, systolic blood pressure, diastolic blood pressure and pulse pressure decreased significantly. Statistical significance was noted in difference between before and after treatment（P〈0.05）. Systolic blood pressure, diastolic blood pres- sure and pulse pressure in observation group after treatment were significantly lower than counterparts in control group, statistical significance was noted（P〈0.05）. CONCLUSION： Amlodipine combined with atorvastatin show sound effect on primary hypertension, lowering blood pressure and pulse pressure.