Effect of Hyperlipoproteinemia on Functional Activity of Peritoneal Macrophages during Tumor Growth

The role of hypercholesterolemia as a factor modulating functional activity of macrophages during the growth of syngeneic transplanted 22a hepatoma in mice was studied. Starting from day 21 after inoculation of tumor cells we observed the development of hyperlipoproteinemia paralleled by an increase in macrophage activity parameters. The total serum cholesterol content and production of nitroxide anions by macrophages were in positive correlation on days 14-35 of tumor growth. We hypothesized that the development of hypercholesterolemia at the late stages of some tumor growth is a factor stimulating production of nitrites and 5'-nucleotidase activity.