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| 异位脂肪沉积致非脂肪组织胰岛素抵抗的研究进展 | |
| 引用本文： | 张华,郑少雄. 异位脂肪沉积致非脂肪组织胰岛素抵抗的研究进展[J]. 医学综述, 2008, 14(4): 572-574 |
| 作者姓名： | 张华 郑少雄 |
| 作者单位： | 天津医科大学第二医院内分泌科,天津,300211 |
| 摘 要： | 脂毒性是指持续的高水平的游离脂肪酸造成的胰岛β细胞和胰岛素靶组织的结构和功能的损害。游离脂肪酸增加,一方面造成胰腺本身的胰岛素抵抗,加剧β细胞的凋亡;另一方面,沉积于肝脏、肌肉等非脂肪组织,造成这些组织的胰岛素抵抗。因此,脂毒性在2型糖尿病的发病中起重要作用。 |
| 关 键 词： | 脂毒性 胰岛素抵抗 游离脂肪酸 凋亡 |
| 文章编号： | 1006-2084（2008）04-0572-03 |
| 收稿时间： | 2007-08-14 |
| 修稿时间： | 2007-10-10 |
Study Progress about Insulin Resistance of Non-fatty Issue Resulting from Allotopic Fatty Deposition |
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| ZHANG Hua,ZHENG Shao-xiong. Study Progress about Insulin Resistance of Non-fatty Issue Resulting from Allotopic Fatty Deposition[J]. Medical Recapitulate, 2008, 14(4): 572-574 | |
| Authors: | ZHANG Hua ZHENG Shao-xiong |
| Affiliation: | ZHANG Hua,ZHENG Shao-xiong.(Department of endocrinology,Second Hospital Affiliated to Tianjin Medical University,Tianjin 300211,Chin) |
| Abstract: | Lipotoxicity refers to the structural and functional damage of β cell of islet and insulin targeted tissue caused by free fatty acid in high level. Increased FFA not only results in insulin resistance in pancreatic gland itself and aggravate the apoptosis of β cell of islet, but also results in insulin resistance in non-fatty tissue by depositing these tissues including liver, muscles and so on. So lipotoxicity plays an important role in the genesis of type 2 diabetes. |
| Keywords: | Lipotoxicity Insulin resistance Free fatty acid Apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |