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| 血清细胞外基质浓度和糖尿病肾病的关系 | |
| 引用本文： | 罗红梅 闫秀兰. 血清细胞外基质浓度和糖尿病肾病的关系[J]. 河南医学研究, 1999, 8(2): 158-159,162 |
| 作者姓名： | 罗红梅 闫秀兰 |
| 作者单位： | 河南医科大学第一附属医院肾内科，河南省济源市人民医院内二科，河南省医学科学研究所内分泌室 |
| 摘 要： | 目的：探讨血清细胞外基质（ＩＶ型胶原，ＣＩＶ和层粘蛋白，ＬＡＭ）浓度与糖尿病肾病的关系。方法：放免法测定患者血清ＣＩＶ、ＬＡＭ浓度。结果：糖尿病肾病组血清ＣＩＶ、ＬＡＭ水平明显高于正常对照组（Ｐ＜００１）及无糖尿病肾病组（Ｐ＜００５）；血清ＣＩＶ、ＬＡＭ值与血糖、病程呈正相关（ｒ分别为０３０和０２６，Ｐ＜００１和Ｐ＜００５）。结论：血清细胞外基质水平的增高可能是引起糖尿病肾病的一个重要原因。 |
| 关 键 词： | Ⅳ型胶原；层粘蛋白；糖尿病肾病 |
The relationship between serum concentrations of extracellular matrix proteins and diabetic nephropathy |
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| Luo HongmeiYan XiulanGuo Changjiang et al. The relationship between serum concentrations of extracellular matrix proteins and diabetic nephropathy[J]. Henan Medical Research, 1999, 8(2): 158-159,162 | |
| Authors: | Luo HongmeiYan XiulanGuo Changjiang et al |
| Abstract: | Objective: To study the possible relationship between serum concentrations of extracellular matrix (ECM) proteins and diabetic nephropathy (DN). XMethods: The levels of serum type collagen (CIV) and laminin (LAM) were determined by radioimmunoassay. Results: The concentrations of serum CIV and LAM in DN group were significantly higher than those in control group (P<001) and diabetic mellitus group (P<005). Serum levels of ECM proteins were positively correlated with blood sugar (r=003,P<001) and course of disease(r=026,P<005). Conclusion: The results suggest that increased serum concentrations of ECM proteins may be a major cause of DN. |
| Keywords: | type collagen laminin diabetic nephropathy |
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