长期不进展者抗HIV-1相关机制的研究进展 |
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引用本文: | 薛秀娟,崔为国,朱谦,王哲. 长期不进展者抗HIV-1相关机制的研究进展[J]. 中国性病艾滋病防治, 2010, 0(6): 618-621 |
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作者姓名: | 薛秀娟 崔为国 朱谦 王哲 |
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作者单位: | 河南省疾病预防控制中心,郑州450016 |
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基金项目: | “十一五”国家重大科技攻关计划项目“艾滋病病人的疾病进展相关因素研究”(2008ZX1001-001) |
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摘 要: | 临床实践调查发现,Ⅰ型艾滋病病毒(HIV-1)感染存在不同的病程进展模式,长期不进展者(LTNPs)是指,在HIV-1感染者中,小部分未接受抗病毒治疗而保持病程长期不进展的个体。然而是什么机制使得这些HIV-1感染者疾病长期不进展?近年来有关LTNPs抗HIV-1的作用机制受到越来越多的关注。文章收集了有关LTNPs最近的研究进展,着重从机体免疫学、宿主遗传学、病毒生物学三方面进行综述。
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关 键 词: | 艾滋病 长期不进展者 作用机制 |
Study on anti-HIV mechanisms in long term non-progressors |
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Affiliation: | XUE Xiu-juan,CUI Wei-guo,ZHU Qian,et al.(Center for Disease Prevention and Control,Zhengzhou Henan,450016,China) |
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Abstract: | Various patterns of HIV-1 disease progression have been described in clinical practice and scientific studies.A subset of individuals who are persistently infected with HIV-1 for years and remain asymptomatic without signs of disease progression in the absence of antiretroviral treatment,are defined as long term nonprogressors(LTNPs).Then what underlying mechanisms are behind ? In this paper,the mechanisms of LTNPs are summarized in the light of immunology,genetics and biology. |
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Keywords: | HIV-1 LTNPs Mechanisms |
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