| 栀子的化学成分、药理作用研究进展及质量标志物预测分析 |
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| 引用本文： | 史永平,孔浩天,李昊楠,李晓彬,张云,韩利文,田青平,刘可春. 栀子的化学成分、药理作用研究进展及质量标志物预测分析[J]. 中草药, 2019, 50(2): 281-289 |
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| 作者姓名： | 史永平 孔浩天 李昊楠 李晓彬 张云 韩利文 田青平 刘可春 |
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| 作者单位： | 山西医科大学药学院, 山西 太原 030001;齐鲁工业大学(山东省科学院)生物研究所, 山东 济南 250103;山东省科学院药物筛选技术重点实验室, 山东 济南 250103,齐鲁工业大学(山东省科学院)生物研究所, 山东 济南 250103;山东省科学院药物筛选技术重点实验室, 山东 济南 250103,齐鲁工业大学(山东省科学院)生物研究所, 山东 济南 250103;山东省科学院药物筛选技术重点实验室, 山东 济南 250103,齐鲁工业大学(山东省科学院)生物研究所, 山东 济南 250103;山东省科学院药物筛选技术重点实验室, 山东 济南 250103,齐鲁工业大学(山东省科学院)生物研究所, 山东 济南 250103;山东省科学院药物筛选技术重点实验室, 山东 济南 250103,齐鲁工业大学(山东省科学院)生物研究所, 山东 济南 250103;山东省科学院药物筛选技术重点实验室, 山东 济南 250103,山西医科大学药学院, 山西 太原 030001,齐鲁工业大学(山东省科学院)生物研究所, 山东 济南 250103;山东省科学院药物筛选技术重点实验室, 山东 济南 250103 |
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| 基金项目： | 山东省重点研发计划（2017YYSP032）；山东省科学院地产学研协同创新基金项目（2017CXY-10） |
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| 摘 要： | 栀子是我国传统的常用中药材,也是我国卫生部发布的第一批药食两用药材。近年来,栀子在药品及保健食品中的应用越来越广泛,因此栀子的品质评价问题也成为了该行业迫切需要解决的关键问题。在对其化学成分及药理作用综述的基础上,结合质量标志物概念,基于化学成分、临床新用途相关性、可测成分、传统药性功效、入血成分和贮藏时间影响等几个方面对栀子质量标志物进行预测分析,为栀子质量评价研究提供科学依据。
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| 关 键 词： | 栀子 环烯醚萜类 栀子苷 质量标志物 质量评价 |
| 收稿时间： | 2018-10-13 |
Research progress on chemical composition and pharmacological effects of Gardenia jasminoides and predictive analysis on quality marker (Q-marker) |
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| SHI Yong-ping,KONG Hao-tian,LI Hao-nan,LI Xiao-bin,ZHANG Yun,HAN Li-wen,TIAN Qing-ping and LIU Ke-chun. Research progress on chemical composition and pharmacological effects of Gardenia jasminoides and predictive analysis on quality marker (Q-marker)[J]. Chinese Traditional and Herbal Drugs, 2019, 50(2): 281-289 |
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| Authors: | SHI Yong-ping KONG Hao-tian LI Hao-nan LI Xiao-bin ZHANG Yun HAN Li-wen TIAN Qing-ping LIU Ke-chun |
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| Affiliation: | School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China;Biology Institute of Qilu University of Technology(Shandong Academy of Sciences), Jinan 250103, China;Key Laboratory for Drug Screening Technology of Shandong Academy of Science, Jinan 250103, China,Biology Institute of Qilu University of Technology(Shandong Academy of Sciences), Jinan 250103, China;Key Laboratory for Drug Screening Technology of Shandong Academy of Science, Jinan 250103, China,Biology Institute of Qilu University of Technology(Shandong Academy of Sciences), Jinan 250103, China;Key Laboratory for Drug Screening Technology of Shandong Academy of Science, Jinan 250103, China,Biology Institute of Qilu University of Technology(Shandong Academy of Sciences), Jinan 250103, China;Key Laboratory for Drug Screening Technology of Shandong Academy of Science, Jinan 250103, China,Biology Institute of Qilu University of Technology(Shandong Academy of Sciences), Jinan 250103, China;Key Laboratory for Drug Screening Technology of Shandong Academy of Science, Jinan 250103, China,Biology Institute of Qilu University of Technology(Shandong Academy of Sciences), Jinan 250103, China;Key Laboratory for Drug Screening Technology of Shandong Academy of Science, Jinan 250103, China,School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China and Biology Institute of Qilu University of Technology(Shandong Academy of Sciences), Jinan 250103, China;Key Laboratory for Drug Screening Technology of Shandong Academy of Science, Jinan 250103, China |
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| Abstract: | Gardenia jasminoides is a traditional Chinese herbal medicine, which is also the first batch of being used for both medicine and food issued by Ministry of Health of China. In recent years, G. jasminoides has been applied widely in medicine and health food, so the quality evaluation of G. jasminoides has become a key problem urgently needed to be solved in this industry. Based on the review of its chemical composition and pharmacological effects, combined with the definition of Q-marker, this study processed predictive analysis on Q-marker of G. jasminoides from several aspects at chemical composition, new clinical use, measurable composition, traditional medicine properties and efficacy, plasma composition, and storage time, which provides the basis for quality evaluation of G. jasminoides. |
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| Keywords: | Gardenia jasminoides Ellis iridoids phenylethanoid glycoside quality marker (Q-marker) quality evaluation |
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