注射用丹参多酚酸治疗急性脑梗死疗效观察

目的 探讨注射用丹参多酚酸治疗急性脑梗死的临床疗效、安全性。方法 将80例急性脑梗死患者随机分为观察组（40例）和对照组（40例），对照组采用常规治疗方法，阿司匹林肠溶片100 mg，每日1次，口服，瑞舒伐他汀钙片10mg，每晚1次，口服，依达拉奉30 mg，每日2次，静脉滴注；观察组在对照组基础上加用注射用丹参多酚酸100 mg，每日1次，静脉滴注，疗程14 d。两组分别在治疗前、后，对患者进行美国国立卫生院神经功能缺损程度评分（NHISS），日常生活活动能力量表评分（Barthel指数），检测血清C反应蛋白水平。结果 观察组总有效率为87.5%，对照组总有效率为57.5%，两组治疗临床效果比较差异显著（P<0.05）；治疗后，两组患者NIHSS评分、C反应蛋白水平明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组显著低于对照组，差异有统计学意义（P<0.05）。治疗后，两组患者Barthel指数明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组显著高于对照组，差异有统计学意义（P<0.05）。观察组仅1例出现短暂性面红情况，减慢静滴速度后消失。两组肝功及心肌酶均在正常范围。结论 注射用丹参多酚酸治疗急性脑梗死疗效显著、安全性好。

Effect of Salvianolic Acid for Injection on acute cerebral infarction

Objective To investigate the clinical efficacy and safety of Salvianolic Acid for Injection in the treatment of acute cerebral infarction. Methods Tatolly 80 patients with acute cerebral infarction were randomly divided into observation group (40 cases) and control group (40 cases). The control group was treated with routine therapy, Aspirin enteric-coated tablets 100 mg, once a day, oral, rosuvastatin calcium tablets 10 mg, once a night, oral, edaravone 30 mg, twice a day, static. Pulse drip, the observation group on the basis of the control group with Salvianolic Acid for Injection 100 mg, once a day, intravenous drip, 14 days for a course of treatment, the two groups before and after treatment, the patients with neurological deficit score (NHISS score), activity of daily living scale score (Barthel Index). Results Compared with the control group, the total effective rate was 87.5% in the observation group and 57.5% in the control group, and the clinical effect was compared between the two groups (P<0.05). After treatment, the NIHSS score and C-reactive protein level of the two groups were significantly lower than those of the control group (P<0.05), and the observation group was significantly lower than that of the control group (P<0.05). After treatment, the Barthel index of the two groups increased significantly, and there was significant difference before and after treatment in the same group (P<0.05); and the observation group was significantly higher than the control group, the difference was statistically significant (P<0.05). In the observation group, only one case had transient blush, which disappeared after slowing down the intravenous drip speed. The liver function and myocardial enzymes in both groups were in normal range. Conclusion salvianolic acid injection is effective and safe in the treatment of acute cerebral infarction.