| 蛇床子酸缓冲温敏型凝胶的制备与体外评价 |
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| 引用本文： | 李金玲,王亚静,石惠姝,王亚楠,商利娜,赵海宁,张怡,周梦楠. 蛇床子酸缓冲温敏型凝胶的制备与体外评价[J]. 天津中医药大学学报, 2019, 38(3): 296-299 |
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| 作者姓名： | 李金玲 王亚静 石惠姝 王亚楠 商利娜 赵海宁 张怡 周梦楠 |
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| 作者单位： | 天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 301617,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 301617,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 301617,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 301617,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 301617,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 301617,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 301617,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 301617 |
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| 基金项目： | 国家"重大新药创制"科技重大专项（2018ZX09721-005）;国家自然科学基金青年项目（81803739,81803862）;天津市新药创制重大专项项目（182XXYSY00130）。 |
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| 摘 要： | ![]()
[目的] 制备蛇床子酸缓冲温敏型凝胶并对其进行体外评价。[方法] 以缓冲能力为指标,筛选酸缓冲体系,以蛇床子为模型药物,泊洛沙姆407和泊洛沙姆188为凝胶材料,采用冷溶法制备温敏凝胶,采用D-最优混料设计,以胶凝温度为指标优化处方,并对优化后处方进行体外评价。[结果] 最优处方为5.0%蛇床子提取物、0.2%尼泊金乙酯、10.0% PEG400、16.4%泊洛沙姆407、5.2%泊洛沙姆188、5.6%乳酸-乳酸钠缓冲体系、57.6%纯化水;优化后温敏凝胶的胶凝温度为（35.1±0.1）℃,pH值为（4.21±0.03）,胶凝时间为（2.4±0.4） s,铺展性良好,黏度适宜,具有缓释作用。[结论] 制得的中药蛇床子凝胶具有温敏、缓释及酸缓冲特性,符合老年性阴道炎局部用药的生理结构特点及用药需求,为老年性阴道炎外用制剂的设计与开发提供参考。
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| 关 键 词： | 老年性阴道炎 蛇床子 温敏凝胶剂 酸缓冲体系 D-最优混料设计法 胶凝温度 |
| 收稿时间： | 2019-01-15 |
Preparation and in vitro evaluation of Cnidium acid buffered temperature-sensitive gel for senile vaginitis |
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| LI Jinling,WANG Yajing,SHI Huishu,WANG Yanan,SHANG Lin,ZHAO Haining,ZHANG Yi and ZHOU Mengnan. Preparation and in vitro evaluation of Cnidium acid buffered temperature-sensitive gel for senile vaginitis[J]. Journal of Tianjin University of Traditonal Chinese Medicine, 2019, 38(3): 296-299 |
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| Authors: | LI Jinling WANG Yajing SHI Huishu WANG Yanan SHANG Lin ZHAO Haining ZHANG Yi ZHOU Mengnan |
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| Affiliation: | Tianjin University of Tradition Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 301617,Tianjin University of Tradition Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 301617,Tianjin University of Tradition Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 301617,Tianjin University of Tradition Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 301617,Tianjin University of Tradition Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 301617,Tianjin University of Tradition Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 301617,Tianjin University of Tradition Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 301617 and Tianjin University of Tradition Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 301617 |
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| Abstract: | ![]()
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| Keywords: | senile vaginitis cnidium temperature-sensitive gel lactic acid buffer D-optimal mixture design senile vaginitis gelation temperature |
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