自噬对血管平滑肌细胞增殖的影响

血管平滑肌细胞异常增殖是血管增殖性疾病的病理基础,自噬是真核生物维持细胞内环境稳态的一种自我保护机制。近年来的研究发现,自噬参与多种细胞因子、血管活性物质、剪切应力、ncRNA等诱导的血管平滑肌细胞增殖,一些抗血管增生性疾病的药物往往通过调节自噬通量和自噬活性发挥抗血管平滑肌细胞增殖作用。本文综述了自噬对血管平滑肌细胞增殖的影响,为探索血管增生性疾病的病理生理机制提供新的思路。

Effect of autophagy on proliferation of vascular smooth muscle cells

Abnormal proliferation of vascular smooth muscle cells is the pathological basis of vascular proliferative diseases. Autophagy is a self-protection mechanism of eukaryote to maintain the stability of intracellular environment. In recent years, the study found that autophagy participates in a variety of cytokines, vascular active substances, shear stress and ncRNA induced vascular smooth muscle cell proliferation, some drugs against vascular proliferative diseases often play the role of anti-proliferation of vascular smooth muscle cells by regulating autophagy flux and autophagy activity. This paper reviews the influence of autophagy on vascular smooth muscle cell proliferation and its mechanism, in order to provide new ideas for further understanding of the pathophysiology of vascular proliferative disease.