Pentacam与AS-OCT测量眼前节生物参数的比较

目的：在两组人群中比较Pentacam眼前节分析仪与眼前节光相干断层扫描(AS-OCT)测量的角膜曲率及角膜散光、中央角膜厚度和前房深度的差异性、相关性及一致性，为临床使用提供参考。

方法：前瞻性临床研究。纳入青年近视术前检查者64例124眼、年龄相关性白内障患者61例85眼，先后使用Pentacam和AS-OCT进行测量，获得眼前节生物参数。在两组人群中采用配对样本t检验分别对两种仪器测量结果的差异性进行比较，所得数据的相关性采用 Pearson相关性分析，测量结果的一致性采用 Bland-Altman 分析。

结果：近视组两种仪器测得的陡峭角膜曲率(Ks)、平坦角膜曲率(Kf)、平均角膜曲率(Km)有显著差异(P<0.001)，而白内障组测得的Ks、Kf、Km无差异(P>0.05)，两组人群两种仪器测量的J₀(散光参数)、平均角膜厚度(CCT)、前房深度(ACD)均有差异(P<0.05)，测得J₄₅(散光参数)无差异(P>0.05)。两组人群中两种仪器测量的Ks、Kf、Km、J₀、J₄₅、CCT及ACD均具有线性相关(P<0.001)。近视组测量的Ks、Kf、Km的一致性良好，而白内障组测量的Ks、Kf、Km的一致性较差。

结论：Pentacam和AS-OCT测量散光参数、CCT及ACD时具有较好一致性，可互换使用，而测量Ks、Kf、Km时的一致性受年龄相关因素影响，优先考虑选择Pentacam。

Comparison of Pentacam and AS-OCT in measuring ophthalmic anterior segment biological parameters

AIM: To compare the difference of corneal curvature, astigmatism, central corneal thickness and anterior chamber depth between the Pentacam anterior segment analyzer and anterior segment optical coherence tomography(AS-OCT)in young myopic preoperative and senile cataract patients.

METHODS: Prospective clinical study.Totally 64 preoperative examinations(124 eyes)and 61 senile cataract patients(85 eyes)were selected. Pentacam and AS-OCT were used to measure the people''s parameters of the ophthalmic anterior segment. Paired sample t-test was used to compare the differences of the two devices'' measurement results of the two groups. The correlation of the obtained data was analyzed by Pearson correlation analysis. The consistency of the measurement results was analyzed by Bland-Altman plot analysis.

RESULTS: There were significant differences in measuring steep Keratometry(Ks), flat Keratometry(Kf)and mean Keratometry(Km)between the two devices of myopia(P<0.001), but there was no statistically significant difference in the cataract group(P>0.05). The astigmatic parameters J₀, central corneal thickness(CCT), and anterior chamber depth(ACD)measured by the devices and there were statistically significant differences between the two devices(P<0.05)while there was no significant difference in the measured astigmatic parameters J₄₅(P>0.05). The results of Ks, Kf, Km, J₀, J₄₅, CCT and ACD measured by the two devices in both groups were linearly related(P<0.001). The Bland-Altman plot analyses showed that the two devices had comparable results for J₀, J₄₅, CCT and ACD. The consistency of Ks, Kf and Km measured by the myopia group was good, while the consistency of Ks, Kf and Km measured by the cataract group was poor.

CONCLUSION: Pentacam and AS-OCT measurements of the ophthalmic anterior segment are consistent with astigmatic parameters, CCT and ACD, and can be used interchangeably. The consistency of Ks, Kf and Km is affected by age related factors, and Pentacam is preferred.