| 山莨菪碱对急性颈髓损伤后血浆及脑脊液中内皮素-1含量的影响 |
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| 引用本文： | 罗晓阳,张建生. 山莨菪碱对急性颈髓损伤后血浆及脑脊液中内皮素-1含量的影响[J]. 中华神经外科疾病研究杂志, 2002, 1(1): 72-74 |
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| 作者姓名： | 罗晓阳 张建生 |
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| 作者单位： | 1. 730070,兰州,解放军473医院神经外科
2. 兰州医学院第二附属医院神经外科 |
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| 摘 要： | 目的：研究山莨菪碱（654－2）对内皮素－1（ET－1）水平的影响。方法：用放免法（RIA）测定急性颈髓损伤患血浆及脑脊液中ET－1含量。结果：急性颈髓损伤后血浆及脑脊液ET－1明显升高，经山莨菪碱治疗组ET－1较创伤对照组明显下降。结论：急性颈髓损伤后神经元坏死可能与ET－1水平升高有关，山莨菪碱可通过降低ET－1水平而发挥对脊髓神经元的保护作用。
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| 关 键 词： | 脊髓损伤 血浆 脑脊液 内皮素 山莨菪碱 |
| 文章编号： | 1671-2897(2002)01-072-03 |
| 修稿时间： | 2001-08-30 |
Effects of anisodamine on levels of endothelin-1 in the plasma and cerebrospinal fluid after acute cervical spinal cord injury |
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| LUO Xiaoyang,ZHANG Jiansheng. Effects of anisodamine on levels of endothelin-1 in the plasma and cerebrospinal fluid after acute cervical spinal cord injury[J]. Chinese Journal of Neurosurgical Disease Research, 2002, 1(1): 72-74 |
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| Authors: | LUO Xiaoyang ZHANG Jiansheng |
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| Affiliation: | LUO Xiaoyang,ZHANG Jiansheng. Department of Neuroswgery,The 473th Hospital of PLA,Lanzhou 730030,China |
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| Abstract: | Objective To investigate the effects of anisodamine (654 -2) on levels of endothelin - 1 (ET-1) in the plasma and cerebrospinal fluid (CSF) after acute cervical spinal cord injury. Methods The levels of ET - 1 in the plasma and CSF after acute cervical spinal cord injury were determined by radioimmunoassay (RIA). Results The levels of ET - 1 in the plasma and CSF increased significantly after acute cervical spinal cord injury and decreased markedly after the therapy of 654 - 2. Conclusion These data suggest that the increasing of ET - 1 may play an important part in causing neuronal death after acute cervical spinal cord injury. And the 654 -2 can protect the cervical spinal cord neurons by decreasing levels of ET - 1. |
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| Keywords: | Spinal cord injury Plasma Cerebrospinal fluid Endothelins Anisodamine |
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