广东鼻咽癌遗传流行病学研究

目的 探讨鼻咽癌高发区遗传流行病学特征。方法 通过鼻咽癌先得及其配偶核心家系群体调查，应用回归Logistic模型拟合方法作鼻咽癌核心家系复合分离分析。结果 先证者一级亲属患鼻咽癌危险性为配偶一级亲属的9．31倍；鼻咽癌的分离比为0.0588(0.0182,0.0994)、遗传度为68．08％；回归Logistic模型拟合以D模型拟合较好。结论 广东人群鼻咽癌遗传倾向更明显、家族聚集性更强。除环境因素及自身基因型外，个体发病与否受其父母及所有比他（她）年长同胞发病情况影响；广东鼻咽癌为多基因遗传病，但存在着影响其发病的单个易感基因。

Study on genetic epidemiology of nasopharyngeal carcinoma in Guangdong, China

Objective To explore the characteristic of genetic epidemiology of nasopharyngeal carcinoma (NPC) in a high risk area--Guangdong province, China. Methods Population investigation was made on the nuclear pedigrees of the first patient with NPC and his/her spouse, and then complex segregation analysis was performed using regressive Logistic model. Results The risk of suffering from NPC is 9.31 times higher in the first degree relatives of patient with NPC than in the first degree relatives of spouse. The separation ratio and heritability are 0.0588(0.0182, 0.0994) and 68.08% respectively. The result of complex segregation analysis shows that model D is better than model A. Conclusion The genetic trend and familial clustering of NPC are more significant and powerful in Guangdong. The risk of suffering from NPC is related with parent's state and senior sibling's state. Nasopharyngeal carcinoma is a multi-gene hereditary disease, but a single gene that decides the susceptibility to NPC may be present.