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颜面皮肤癌VEGF和NOS表达及相关性
引用本文:李晓光,王延秀,闫立勇,杨宪勇,王青. 颜面皮肤癌VEGF和NOS表达及相关性[J]. 中国肿瘤, 2004, 13(7): 440-442
作者姓名:李晓光  王延秀  闫立勇  杨宪勇  王青
作者单位:山东省泰安市中心医院,山东,泰安,271000
摘    要:
[目的]研究血管内皮生长因子(VEGF)、诱导型一氧化氮合酶(iNOS)和内皮型一氧化氮合酶(eNOS)在颜而皮肤癌的表达及其相关性.[方法]应用免疫组化方法检测47例颜面皮肤癌标本VEGF、iNOS和eNOS的表达,并对其相关性进行统计分析.[结果]47例颜面皮肤癌组织中,表达iNOS、eNOS、VEGF的分别为63.83%、74.47%、68.09%;VEGF与iNOS的表达具有明显相关性(P<0.01),VEGF与eNOS的表达无明显相关性(P>0.05);VEGF的表达与颜面皮肤癌肿瘤分化程度呈正相关,与临床分期及病理分型无关.iNOS表达与颜面皮肤癌的分化程度及临床分期呈正相关,与病理分型无关.eNOS表达与颜面皮肤癌病理分型、临床分期和分化程度均无关.[结论]VEGF与iNOS的表达具有明显相关性,iNOS和VEGF在肿瘤生成过程中起重要作用.

关 键 词:血管内皮生长因子  一氧化氮  颜面  皮肤肿瘤
文章编号:1004-0242(2004)07-0440-03

Expressions of Vascular Endothelial Growth Factor and Nitric Oxide Synthase in Facial Skin Carcinoma and Their Correlation
LI Xiao-guang,WANG Yan-xiu,YAN Li-yong,et al.. Expressions of Vascular Endothelial Growth Factor and Nitric Oxide Synthase in Facial Skin Carcinoma and Their Correlation[J]. CHINA CANCER, 2004, 13(7): 440-442
Authors:LI Xiao-guang  WANG Yan-xiu  YAN Li-yong  et al.
Abstract:
To investigate the expression of inducible nitric oxide synthase(iNOS),endothelial nitric oxide synthase(eNOS) and vascular endothelial growth factor(VEGF) in facial skin carcinoma and their correlation.Tissue samples from 47 patients with facial skin carcinoma were examined using immunohistochemistry technique for detection the expressions and carrelation of iNOS,eNOS and VEGF.Positive iNOS?eNOS and VEGF immunostaining were detected in 63.83%?74.47% and 68.09% respectively.Expression of VEGF had a significant positive correlation to iNOS(P<0.01) but not to eNOS(P>0.05). VEGF expression has positive correlation with the differentiation of facial skin carcinoma,negative with clinical stage and pathologic type.While iNOS expression has positive correlation with differentiation and clinical stage,negative with pathologic type,eNOS expression had no correlation to patologic type,clinical stage and differentiation.[Conclusion]VEGF and iNOS have a significant positive correlation in facial skin carcinoma, and play important roles in cancer development.
Keywords:vascular endothelial growth factor(VEGF)  nitric oxide synthase(NOS)  face  skin neoplasms  
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