| 来得时(甘精胰岛素)联合文达敏对初诊2型糖尿病治疗有效性及对β细胞功能变化的影响 |
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| 引用本文： | 谭丽玲,宋钦华. 来得时(甘精胰岛素)联合文达敏对初诊2型糖尿病治疗有效性及对β细胞功能变化的影响[J]. 现代预防医学, 2011, 38(4): 771-772 |
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| 作者姓名： | 谭丽玲 宋钦华 |
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| 作者单位： | 海南省海南医学院附属医院老年内分泌科,海口,570102 |
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| 摘 要： | [目的]比较来得时(甘精胰岛素)联合文达敏(二甲双胍马来酸罗格列酮)与预混胰岛素注射两种方案的血糖控制情况和对胰岛细胞功能的影响。[方法]46例初次诊断的2型糖尿病患者随机分成来得时联合口服文达敏组(A组,n=25)和预混人胰岛素30R皮下注射组(B组,n=21),治疗3个月。测定每组治疗前后FPG、2hPG、糖化血红蛋白(HbA1c)、体重指数(BMI)、胰岛素、C-肽,计算胰岛细胞功能指数(Homa-β)、胰岛素抵抗指数(Homa-IR)。[结果]两组治疗后FBG、2hPG、HbA1c较治疗前明显下降(P﹤0.01);Homa-β较治疗前明显增加,Homa-IR明显下降,差异均有统计学意义(P﹤0.01)。组间Homa-β、Homa-IR比较也有统计学差异,A组胰岛素用量与B组的差异有统计学意义(P﹤0.01)。[结论]来得时联合口服文达敏治疗初诊2型糖尿病患者不仅能有效控制血糖,而且能较好改善β细胞功能,使用方便、患者依从性好,低血糖发生率低。
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| 关 键 词： | 2型糖尿病 来得时 β细胞功能 |
THE EFFECT OF B-CELL FUNCTION ON LANTUS WITH AVANDAMENT IN THE TREATMENT OF NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS |
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| TAN Li-ling,SONG Qin-hua. THE EFFECT OF B-CELL FUNCTION ON LANTUS WITH AVANDAMENT IN THE TREATMENT OF NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS[J]. Modern Preventive Medicine, 2011, 38(4): 771-772 |
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| Authors: | TAN Li-ling SONG Qin-hua |
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| Affiliation: | TAN Li-ling,SONG Qin-hua.(Department of Endocrinology,the Hospital Affiliated to Hainan Medical University,Haikou 570102,China) |
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| Abstract: | [Objective] To study the effects of co-administration insulin and avandament on the change of beta-cell function and insulin resistance in primary type 2 diabetes mellitus patients.[Methods] All the patients were divided into two groups,and treated with 3 months.Glargine(the group A,n = 25) and Premix insulin(the group B,n = 21) examined their fasting blood glucose,2 hours postprandial glucose(2hPG),glycosylated hemoglobin A1c(HbAlc),lnsulin and C-peptide.We counted the insulin sensitivity index and insulin... |
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| Keywords: | Lantus Avandament Type 2 diabetes mellitus Beta-cell function of insulin |
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