| 卡氏肺孢子虫kexin蛋白抗原表位预测 |
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| 引用本文： | 朱丹丹,段义农,陈金铃. 卡氏肺孢子虫kexin蛋白抗原表位预测[J]. 现代预防医学, 2011, 38(6): 1077-1079 |
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| 作者姓名： | 朱丹丹 段义农 陈金铃 |
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| 作者单位： | 南通大学医学院人体寄生虫学教研室,南通,226001 |
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| 基金项目： | 南通市应用研究计划资助 |
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| 摘 要： | [目的]预测卡氏肺孢子虫kexin蛋白的抗原表位。[方法]应用互联网服务器及相关生物软件预测卡氏肺孢子虫kexin蛋白抗原表位,进行生物信息学分析。[结果]kexin蛋白存在多个潜在的抗原表位,其中T细胞表位按积分位于第367～381,38～52,128～156,351～388,426～440位氨基酸等区域,B细胞表位位于第133～215,300～442及660～733位氨基酸区域。[结论]kexin抗原表位可能主要位于第38～215及300～442氨基酸序列区域内或其附近,抗原表位的预测可以有目的地克隆kexin重组基因片段,为研究高效卡氏肺孢子虫疫苗奠定基础。
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| 关 键 词： | 卡氏肺孢子虫 kexin蛋白 抗原表位 生物信息学 |
PREDICTIONG ON the ANTIGENIC EPITOPES OF THE KEXIN PROTEIN FROM PNEUMOCYSTIS CARINII |
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| ZHU Dan-dan,DUAN Yi-nong,CHEN Jin-ling. PREDICTIONG ON the ANTIGENIC EPITOPES OF THE KEXIN PROTEIN FROM PNEUMOCYSTIS CARINII[J]. Modern Preventive Medicine, 2011, 38(6): 1077-1079 |
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| Authors: | ZHU Dan-dan DUAN Yi-nong CHEN Jin-ling |
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| Affiliation: | ZHU Dan-dan,DUAN Yi-nong,CHEN Jin-ling.(Department of Parasitology,School of Medicine,Nantong University,Nantong 226001,China) |
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| Abstract: | [Objective]To predict the epitopes of Pneumocystis carinii kexin protein.[Methods]By using the internet server and some software,we predicted the epitopes and analyze the bioinformatics of Pneumocystis carinii kexin protein.[Results]Multiple potential antigenic epitopes were predicted to be present in kexin protein of Pneumocystis carinii.Based on the prediction scores,the T cell epitopes were located at amino acid 367-381,38-52,128-156,351-388 and 426-440 residues,respectively,while the B cell epitopes wer... |
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| Keywords: | Pneumocystis carinii Kexin protein Epitope Bioinformatics |
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