Effect of carbidine on dopamine turnover in the rat corpus striatum

It has been shown that carbidine increases the level of homovanillic acid (HVA) in the corpus striatum of the rat brain. The changes in HVA level allowed forming a judgement on dopamine turnover. By the intensity of this effect, carbidine proved inferior to typical neuroleptics--triphtazine and ftorfenazin. The antidepressant ftoracizin did not alter HVA level. Carbidine ranks between neuroleptics and antidepressants in terms of the effect on dopamine turnover.