脐血瘦素及IGF和胰岛素水平与胎儿生长发育相关性研究

目的:探讨脐血瘦素、胰岛素样生长因子(IGF)和胰岛素水平与胎儿生长发育的相关性。方法:采用放射免疫法检测80例足月新生儿脐血瘦素、IGF-I、IGF-II和胰岛素水平,根据胎龄和新生儿出生体重将新生儿分为小于胎龄儿(SGA)、适于胎龄儿(AGA)和大于胎龄儿(LGA)3组,采用新生儿出生时体重、身长和Rohrer's指数估测胎儿生长发育状态。结果:LGA组脐血瘦素、IGF-I和胰岛素水平明显高于AGA组(12.03±1.22vs7.11±1.00,70.21±3.23vs43.48±0.96,4.03±1.12vs3.19±0.92),SGA组脐血瘦素、IGF-I和胰岛素水平明显低于AGA组(2.66±1.03vs 7.11±1.00,22.13±5.98vs43.48±0.96,2.34±3.63vs3.19±0.92);脐血瘦素水平与胎儿出生体重、身长和Rohrer's指数呈显著正相关,LGA和AGA组脐血IGF-I和胰岛素水平与胎儿出生体重、身长和Rohrer's指数呈显著正相关,LGA和AGA组脐血瘦素水平与IGF-I和胰岛素呈显著正相关。结论:脐血瘦素、IGF-I和胰岛素水平与新生儿的体重、身长和Rohrer's指数存在相关性,提示瘦素、IGF-I和胰岛素在胎儿生长发育中起重要作用。

Investigate the relativity of cord blood leptin, IGF and Insulin levels with fetal growth

Objective:To investigate the relativity of the levels of cord blood leptin and Insulin-like growth factor(IGF) with fetal growth and development.Methods:The levels of cord blood leptin,IGF-I,IGF-II and Insulin in 80 term newborns were examined by radio immunoassay(RIA).Results:The levels of cord blood leptin,IGF-I and Insulin in LGA were significantly higher than those in AGA.The levels of cord blood leptin,IGF-I and Insulin in SGA were significantly lower than those in AGA.The cord blood leptin levels correlated positively with birth weight,birth height and Rohrer's,the levels of cord blood IGF-I and Insulin correlated positively with birth weight,birth height and Rohrer's in LGA and AGA,and the leptin levels.correlated positively with IGF-I and Insulin in LGA and AGA.Conclusion:These are relativity that the levels of cord blood leptin,IGF-I and Insulin.correlated positively with birth weight,birth height and Rohrer's.It suggests that leptin,IGF-I and Insulin play an important role in regulation of fetal growth.