急诊经皮冠状动脉介入治疗术后超敏C反应蛋白水平与心肌灌注和心血管事件的相关性

目的 评价急性ST段抬高心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)后超敏C反应蛋白(hs-CRP)水平与心肌灌注和心血管事件的相关性.方法 入选发病12h内120例成功接受PCI的STEMI患者进行hs-CRP检测,根据hs-CRP水平分为正常组和升高组.随访6个月,记录各组心血管事件.结果 (1)急诊PCI后升高组患者TIMI心肌灌注分级(TMPG)0～1级所占比例高于正常组(36.0％比11.8％,P＜0.05),TMPG达3级所占比例低于正常组(58.1％比82.4％,P＜0.05)；(2)随访6个月时升高组心血管事件的发生率明显高于正常组(30.2％比14.7％,P＜0.05).结论 STEMI患者PCI后hs-CRP升高提示心肌灌注差；PCI后hs-CRP早期监测有利于急性心肌梗死PCI后临床预后的评价.

Study on the relationship between high sensitivity C-reactive protein level, myocardial perfusion and cardiovascular events after percutaneous coronary intervention

Objective To evaluate the relationship between high sensitivity C-reactive protein（hs-CRP） level, myocardial perfusion and cardiovascular events after percutaneous coronary intervention （PCI） for ST-segment elevation acute myocardial infarction（STEMI） patients. Methods 120 cases of STEMI patients received hs-CRP detection after PCI. were selected The patients were divided into the normal hs-CRP group and elevated hs-CRP group according to the hs-CRP levels. Following up for six months, the cardiovascular events of two groups were recorded. Results （ 1 ）After PCl,the percentage of TIMI myocardial perfusion grade （TMPG） 0 - 1 in the elevated hs-CRP group was higher than that in the normal hs-CRP group, and the percentage of TMPG 3 in the elevated hs-CRP group was lower than that in the normal hs-CRP group （ P 〈 0.05 ） ; （2） Following up for six months, the incidence of cardiovascular events in the elevated hs-CRP group was significantly higher than that in the normal hs-CRP group （ P 〈 0. 05 ）. Conclusion For STEMI patients after PCI,the increasing of hs-CRP indicated the poorly of myocardial perfu- sion;the early monitoring of hs-CRP was helpful to evaluate the prognosis of acute myocardial infarction after PCI.