甲磺酸罗哌卡因与盐酸罗哌卡因硬膜外麻醉的临床研究

目的：比较甲磺酸罗哌卡因与盐酸罗哌卡因硬膜外麻醉的Ⅱ期临床效果和安全性。方法：3个中心124例择期在低位硬膜外麻醉下行经腹子宫切除术、膀胱部分切除术等手术的患者随机均分为2组：A组注入0．75％盐酸罗哌卡因15ml．B组注入0．894％甲磺酸罗哌卡因15ml。结果：不论是在感觉和运动阻滞的起效时点分布、效果及效果维持时长方面，还是在维持相对稳定的循环、呼吸、肝肾功能等方面，甲磺酸罗哌卡因均表现出良好的作用，与盐酸罗哌卡因无明显差异，二者均无严重不良反应。结论：甲磺酸罗哌卡因与盐酸罗哌卡因具有相似的硬膜外麻醉的临床效果和安全性。

Clinical comparison of the efficacy and safety of epidural ropivacaine mesylate and ropivacaine hydrochloride

AIM: To compare the efficacy and security of epidural ropivacaine mesylate clinically with ropivacaine hydrochloride in a randomized double-blind multicentre study. METHODS: One hundred and twenty-four elective patients from three centres, undergoing lower epidural anesthesia for intraperitoneal hysterectomy, partial cystectomy and so on, were randomly assigned to two equal groups received 15 ml of either 0.75% ropivacaine hydrochloride or 0.894% ropivacaine mesylate. RESULTS: There were no significant differences found in the onset, extent, and duration of sensory and motor block, and also in the hemodynamic stability. When ropivacaine mesylate was clinically compared with ropivacaine hydrochloride. No serious adverse events were found in this study. CONCLUSION: Epidural ropivacaine mesylate is similar to ropivacaine hydrochloride in both efficacy and safety.