多烯磷脂酰胆碱胶囊对原发性肝癌介入治疗的效果及生存质量的影响

目的 探讨多烯磷脂酰胆碱胶囊对原发性肝癌介入治疗的效果及生存质量的影响.方法 选取原发性肝癌患者76例,将其随机分成对照组和观察组,每组各38例.对照组给予经导管肝动脉化疗栓塞治疗,观察组同时联合多烯磷脂酰胆碱胶囊治疗.结果 治疗后,丽组的血清AFP、AFU水平较治疗前均大幅降低,观察组的血清AFP、AFU水平降低程度明显高于对照组（P＜0.01）;观察组的肝功能分级控制率为89.47％,高于对照组的68.42％（P＜0.05）;观察组的骨髓抑制、白细胞减少、恶心呕吐以及血小板减少等不良反应发生率低于对照组（P＜0.05）;观察组的病灶控制率为84.21％,高于对照组的63.16％ （P＜0.05）;观察组的躯体、社会、心理以及症状/副作用方面的得分均高于对照组（P＜0.01）.结论 多烯磷脂酰胆碱胶囊对原发性肝癌能够进一步强化治疗效果,疗效确切,有助于肝功能的改善,同时可提高患者出院后的生存质量.

Effect of polyene phosphatidylcholine capsule for interventional therapy on primary hepatic carcinoma and its influence on quality of life

Objective To explore the effect of polyene phosphatidylcholine capsule for interventional therapy on primary hepatic carcinoma and its influence on quality of life. Methods 76 patients with primary hepatic carcinoma were evenly divided into the control group （n=38） and observation group （n=38） in random.In the control group,transcatheter arterial chemoembolization （TACE） was provided,while in the observation group,polyene phosphatidyleholine capsule was adopted on the basis of the control group. Results After treatment, the level of serum AFP and AFU were decreased greatly in comparison with those before treatment,but reduction degree on the level of serum AFP and AFU in the observation group was higher to that in the control group （P〈0.01）.In the observation group,the control rate of clas- sification on liver function （89.47%） was higher than that in the control group accounting （68.42%） （P〈0.05）. Incidence rate of adverse reactions like myelosuppression,leueopenia,nausea and vomiting,and thromboeytopenia,ete, were lower than those in the control group （P〈0.05）.The control rate of focus in the observation group （84.21%） was higher than that in the control group （63.16%） （P〈0.05）.Score of body,society,mind and symptom/side effect were all higher than those in the control group （P〈0.01）. Conclusion For primary hepatic carcinoma,polyene phosphatidylcholine capsule can further strengthen the therapeutic effect and obtain a definite effect,which is beneficial to improvement of liver function as well as quality of life after discharge of patients.