瑞舒伐他汀对慢性心力衰竭合并肾功能不全患者的疗效观察

目的 观察瑞舒伐他汀治疗慢性心力衰竭合并肾功能不全的临床疗效.方法 回顾性分析2010年2月至2013年2月我院住院治疗的72例慢性心力衰竭合并肾功能不全患者的临床记录资料,所有患者均给予心力衰竭基础治疗,给予瑞舒伐他汀的患者作为治疗组,未给予的患者作为对照组.比较治疗6月后两组患者心功能和肾功能的变化.结果 治疗6个月后,治疗组心功能改善的总有效率显著高于对照组（P＜0.05）;左室射血分数较治疗前明显增高（P＜0.05）,左室舒张末期内径、左室收缩末期内径较治疗前缩小（P＜0.05）,且均优于对照组（P＜0.05）;血尿素氮、肌酐、β2-微球蛋白较对照组明显降低（P＜0.05）.结论 在常规抗心衰治疗的基础上联合使用瑞舒伐他汀,可以改善慢性心力衰竭患者的心功能及肾功能.

The effects of Rosuvastatin in patients with chronic heart failure complicated with chronic renal dysfunction

Objective To observe the effects of Rosuvastatin in patients with chronic heart failure complicated with chronic renal dysfunction.Methods The clinical dataof 72 cases with chronic heart failure complicated with chronic renal dysfunction were retrospective analyzedin our hospitalfrom 2010 February to 2013 February.The cardiac function and renal function were compared after 3 months therapy between two groups.All patients were given basic treatment for heart failure.Cases given Rosuvastatin were as treatment group,while cases with no Rosuvastatin were as control group.Results After 3 months,the overall efficiency of heart function improved in significantly higher than that of the control group （P＜0.05）.After 3 months of carvidilol therapy left ventricular ejection fraction improved（P＜0.05）,while the Iefi ventricular end-diastolic dimension and left ventricular end-systolic dimension were decreased significantly in treatment group （P＜0.05）.The blood urea nitrogen,serum creatinine and blood β2-microglobulin（P＜0.05）.All of these results in treatment group were better than those in control group （P＜0.05）.Condusion Rosuvastatin treatment of chronic heart failure with renal insufficiency significantly,can significantly improve cardiac function and renal function,worthy of popularization.