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| 氯硝基安定抗惊厥作用耐受及停药前后对大鼠下丘脑室旁核CRHmRNA表达的影响 | |
| 引用本文： | 廖建湘,王丽,左启华,孟书聪. 氯硝基安定抗惊厥作用耐受及停药前后对大鼠下丘脑室旁核CRHmRNA表达的影响[J]. 中国药理学通报, 1996, 0(1) |
| 作者姓名： | 廖建湘 王丽 左启华 孟书聪 |
| 作者单位： | 北京医科大学第一医院儿科，深圳市人民医院儿科，北京医科大学细胞生物学系 |
| 摘 要： | 氯硝基安定抗惊厥作用耐受性及依赖性机制目前尚不清楚。近来发现促肾上腺皮质激素释放激素（ＣＲＨ）具有促惊厥作用，并参与应激过程。我们用原位杂交方法观察了氯硝基安定抗大鼠点燃惊厥耐受及停药前后下丘脑室旁核ＣＲＨｍＲＮＡ表达的变化，发现耐受时ＣＲＨｍＲＮＡ表达增强，停药７ｄ时不再变化。提示ＣＲＨ参与了耐受性与依赖性过程。 |
| 关 键 词： | 氯硝基安定；药物依赖性；点燃效应；原位杂交；CRH |
CRH mRNA expression increased in amygdala-kindled rats with tolerance to and dependence on the anticonvulsant effect of clonazepan |
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| LIAO Jian-Xiang,WANG Li,ZUO Chi-Hua, MENG Shu-Cong. CRH mRNA expression increased in amygdala-kindled rats with tolerance to and dependence on the anticonvulsant effect of clonazepan[J]. Chinese Pharmacological Bulletin, 1996, 0(1) | |
| Authors: | LIAO Jian-Xiang WANG Li ZUO Chi-Hua MENG Shu-Cong |
| Abstract: | Mechanisms underlying tolerance to and dependence on anticonvulsant effect of clonazepam are not clear.With in situ hybridization we found CRH mRNA expression increased significantly at paraventricular hypothalamic nucleus in amygdala-kindled rats which had developed tolerance to the anticonvulsant effect of clonazepam,and on day 7 of clonazepam discon tinuation CRH mRNA expression no longer changed.Results indicated that CRH was involved in the development of tolerance to and dependence on the anticonvulsant effect of clonazepam. |
| Keywords: | clonazepam drug-tolerance drug-dependence CRH in situ hybridization |
| 本文献已被 CNKI 等数据库收录！ | |