| Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats |
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| 引用本文： | HUANG Yu-Wen,CHEN Zhong~2,HU Wei-Wei,ZHANG Li-San,WU Wei,YING Li-Yang,WEI Er-Qing Department of Neurobiology and Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310031,China. Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats[J]. Acta pharmacologica Sinica, 2003, 0(12) |
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| 作者姓名： | HUANG Yu-Wen CHEN Zhong~2 HU Wei-Wei ZHANG Li-San WU Wei YING Li-Yang WEI Er-Qing Department of Neurobiology and Pharmacology School of Medicine Zhejiang University Hangzhou 310031 China |
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| 作者单位： | HUANG Yu-Wen，CHEN Zhong~2，HU Wei-Wei，ZHANG Li-San，WU Wei，YING Li-Yang，WEI Er-Qing Department of Neurobiology and Pharmacology，School of Medicine，Zhejiang University，Hangzhou 310031，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China (№ 30000019)，Zhejiang Provincial Natural Science Foundation of China (№ 300062)，partly supported by the Scientific Research Foundations for the Returned Overseas Chinese Scholars. |
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| 摘 要： | AIM: To investigate whether or not histamine is involved in spatial memory deficits induced by dizocilpine (MK-801) as evaluated by 8-arm radial maze of rats. METHODS: 8-Arm (4-arm baited) radial maze was used to measure spatial memory in rats. RESULTS: Bilaterally intrahippocampal (ih) injection of MK-801 (0.3 μg/site) impaired working memory and reference memory in rats. Both histamine (50, 100 ng/site, ih) and intraperitoneal (ip) injection of histidine (100, 200 mg/kg) markedly improved the spatial memory deficits induced by MK-801. On the other hand, the ameliorating effect of histidine (100 mg/kg, ip) was completely antagonized by α-fluoromethylhistidine (α-FMH, 5 μg/site, ih), a potent and selective histidine decarboxylase (HDC) inhibitor, and H_1-antagonist pyrilamine (1 μg/site, ih), but not by H_2-antagonist cimetidine, even at a high dose (2.5 μg/site, ih). CONCLUSION: The hippocampal histamine plays an important role in the ameliorating effect on MK-801-induced spatial memory deficits,
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Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats |
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| HUANG Yu-Wen,CHEN Zhong,HU Wei-Wei,ZHANG Li-San,WU Wei,YING Li-Yang,WEI Er-Qing. Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats[J]. Acta pharmacologica Sinica, 2003, 0(12) |
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| Authors: | HUANG Yu-Wen CHEN Zhong HU Wei-Wei ZHANG Li-San WU Wei YING Li-Yang WEI Er-Qing |
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| Affiliation: | HUANG Yu-Wen,CHEN Zhong~2,HU Wei-Wei,ZHANG Li-San,WU Wei,YING Li-Yang,WEI Er-Qing Department of Neurobiology and Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310031,China |
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| Abstract: | |
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| Keywords: | histamine maze learning dizocilpine memory disorders |
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