Changes in urinary ion excretion and related renal enzyme activities in fluoride-treated rats |
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| Authors: | Yasunobu Suketa Eiichi Mikami |
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| Affiliation: | Department of Environmental Health, Shizuoko College of Pharmacy, Shizuoka 422, Japan |
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| Abstract: | Fluoride (NaF, 50 mg/kg po) administration to rats caused an increased urinary excretion of inorganic phosphate, calcium, magnesium, potassium, and sodium associated with polyuria. The renal enzyme activities of Na+ and K+-stimulated adenosine triphosphatase [(Na+ + K+)-ATPase], Mg2+ and Ca2+-stimulated adenosine triphosphatase [(Mg2+ + Ca2+)-ATPase], acid phosphatase, and alkaline phosphatase were decreased by single oral doses of fluoride. A decrease in renal (Na+ + K+)-ATPase activity was associated with an increase in urine volume and a decrease in serum sodium concentration. |
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