| 脑梗死患者血清中同型半胱氨酸和超敏C-反应蛋白水平观察 |
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| 引用本文： | 张祥,刘晓英. 脑梗死患者血清中同型半胱氨酸和超敏C-反应蛋白水平观察[J]. 中国临床神经科学, 2009, 17(1) |
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| 作者姓名： | 张祥 刘晓英 |
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| 作者单位： | 复旦大学神经病学研究所,200040;附属华山医院神经科,200040 |
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| 摘 要： | 目的:观察急性脑梗死(CI)患者血清中总同型半胱氨酸(tHcy)和超敏C-反应蛋白(hs-CRP)水平同疾病严重程度以及两者之间的关系。方法:采用高效液相色谱-荧光检测定量分析和免疫散射比浊法定量分析检测110例CI组、37例其他神经系统疾病组和105名正常对照组的tHcy和hs-CRP。结果:CI组tHcy水平同其他神经系统疾病组比较差异无统计学意义(P>0.05),而高于正常对照组水平(P<0.05);CI组hs-CRP水平高于其他对照组(P<0.05)。所有CI患者依据NIHSS评分再分为≤5分、5～15分以及≥15分3个亚组。所观察CI患者tHcy平均值(22.24±16.59)μmol·L~(-1),3组tHcy差异无统计学意义(P>0.05);hs-CRP平均值(3.29±2.51)mg·L~(-1),3组间hs-CRP水平比较差异有显著统计学意义(P<0.01);tHcy水平与hs-CRP水平无相关性(P>0.05)。结论:高tHcy与高hs-CRP是脑血管病的危险因素;高tHcy并不是CI的特异性指标,在其他神经系统疾病中也可升高;hs-CRP水平同疾病的严重程度相关;两者的升高可能存在不同的...
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| 关 键 词： | 脑梗死 同型半胱氨酸 超敏C-反应蛋白 |
Observation about the Levels of Homocysteine and High Sensitivity C-reactive Protein in Serum of Acute Ischemic Stroke |
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| ZHANG Xiang,LIU Xiao-Ying. Observation about the Levels of Homocysteine and High Sensitivity C-reactive Protein in Serum of Acute Ischemic Stroke[J]. Chinese Journal of Clinical Neurosciences, 2009, 17(1) |
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| Authors: | ZHANG Xiang LIU Xiao-Ying |
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| Affiliation: | ZHANG Xiang; LIU Xiao-Ying Institute of Neurology; Huashan Hospital; Fudan University; Shanghai 200040; China; |
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| Abstract: | Aim:To observe the levels of total homocysteine(tHcy) and high sensitivity C-reactive protein (hs-CRP),the relationship with the severity of acute cerebral ischemic(CI).Methods:The levels of tHcy and hs-CRP of 110 CI patients,37 patients of other neurological diseases(OND) and 105 healthy volunteers were examined by high performance liquid chromatography(HPLC) and turbidimetry respectively.Results:Levels of tHcy in CI are not different with OND group while being higher than NC group;Levels of hs-CRP in CI a... |
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| Keywords: | cerebral ischemic homocysteine high sensitivity C-reactive protein |
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