氟康唑致固定性药疹

1例28岁女性患者因念殊菌性阴道炎口服氟康唑150mg。3h后在双侧腋下、肘部、足趾等部位出现约1．5～6cm。大小不等的紫红斑块，伴局部肿胀和瘙瘁。患者既往有药物不良反应史，服用阿司匹林和磺胺药后在上述相同部位出现药疹。因此，该斑块诊断为固定性药疹。停用氟康唑，服用氯雷他定10mg，1次／d，维生素C0．2g，3次／d，外用糖皮质激素软膏。1周后，局部肿胀、瘙瘁消退，留下色素沉着。

Fixed drug eruption induced by fluconazol

A-28-year-old woman took fluconazol 150 mg for monilial vaginitis. Three hours later, the woman developed purplish red erythema of varying sizes （ 1.5 - 6 cm^2 ） with swelling and pruritus on bilateral armpits, elbows, and toes. The patient had a previous history of adverse drug reactions, and had developed drug eruptions at the above-mentioned same site after taking aspirin and sulfonamide. Therefore, the erythema was diagnosed as fixed drug eruption. Fluconazal was withdrawn. After treatment with loratadine 10 mg once daily, vitamin C 0.2 g twice daily, and external glucocorticosteroid cream. One week later, her swelling and prurities resolved, and residual pigmentation was left.