Prediction of gestational diabetes mellitus by first trimester serum secreted frizzle-related protein-5 levels |
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| Authors: | Efser Oztas Sibel Ozler Ebru Ersoy Ali Ozgur Ersoy Aytekin Tokmak Merve Ergin |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey, and efseroztas@gmail.com;3. Department of Obstetrics and Gynecology, Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey, and;4. Department of Clinical Biochemistry, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey |
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| Abstract: | ![]()
Objective: The main aim of this study was to investigate the first trimester maternal serum secreted frizzle-related protein-5 (Sfrp-5) levels and to evaluate the predictive value on the subsequently developed gestational diabetes mellitus (GDM).Methods: A total of 40 pregnant women who subsequently developed GDM and 44 age- and pre-pregnancy BMI-matched healthy pregnant women were enrolled in this prospective case-control study. First trimester serum Sfrp-5 levels were evaluated to determine if there is an association with the onset of GDM, by using logistic regression analysis.Results: Decreased first trimester serum Sfrp-5 levels (OR?=?14.332, 95%CI: 4.166–49.301, p?p?>?0.05).Conclusions: Decreased first trimester serum Sfrp-5 levels are significantly associated with the increased risk of GDM. |
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| Keywords: | Adverse perinatal outcomes gestational diabetes mellitus secreted frizzle-related protein-5 |
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