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| 5-HT2C受体在癫患者脑组织的表达 | |
| 引用本文： | 龚玉来,伍雪英,何进宇,徐亚欧,刀筱芳,谢怡,沈阅. 5-HT2C受体在癫患者脑组织的表达[J]. 脑与神经疾病杂志, 2010, 18(4) |
| 作者姓名： | 龚玉来 伍雪英 何进宇 徐亚欧 刀筱芳 谢怡 沈阅 |
| 作者单位： | 1. 三六三医院神经内科,成都,610041 2. 西南民族大学生命科学与技术学院 |
| 摘 要： | 目的研究5-羟色胺2C受体(5-HT2C受体)在癫患者脑组织的表达,探索其临床意义。方法用免疫组化方法检测46例癫患者术后脑组织5-HT2C受体的表达,研究比较不同部位不同病程脑组织表达。结果癫患者额叶脑组织5-HT2C受体的含量较颞叶海马明显增高,长病程组表达低于短病程组。结论 5-HT2C受体可能参与了癫的发病机制,改变5-HT2C受体的表达有望成为癫新的治疗靶点。 |
| 关 键 词： | 癫 5羟色胺2C受体 免疫组化 |
Over expression of 5-HT 2C receptors in epilepsy brain tissue |
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| GONG Yu-lai,WU Xue-ying,HE Jin-yu,XU Ya-ou,DAO Xiao-fang,XIE Yi,SHEN Yue. Over expression of 5-HT 2C receptors in epilepsy brain tissue[J]. Journal of Brain and Nervous Diseases, 2010, 18(4) | |
| Authors: | GONG Yu-lai WU Xue-ying HE Jin-yu XU Ya-ou DAO Xiao-fang XIE Yi SHEN Yue |
| Affiliation: | GONG Yu-lai; WU Xue-ying; HE Jin-yu; XU Ya-ou; DAO Xiao-fang; XIE Yi; SHEN Yue. Department of Neurology; San Liu San Hospital; Chengdu 610041; China; |
| Abstract: | Objective To investigate the expression of 5-hydroxytryptamine(5-HT or serotonin)2C receptors in epilepsy brain tissues and explore the clinical signification of it.Methods 5-HT 2C receptors level was detected in 46 epilepsy patients operation sample by immunohistochemistry method,compared with different part of brain tissues.Results The expression of 5-HT 2C receptors in frontal group was significantly higher than that in temporal and hippocampus group in epilepsy patients,those with course more than 10 y... |
| Keywords: | Epilepsy 5-Hydroxytryptamine 2C receptors Immunohistochemistry |
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