种植体早期边缘骨吸收的相关因素研究

目的探讨TNFA-308基因多态性、吸烟、年龄等因素是否与骨内种植体Ⅱ期手术前边缘骨吸收有关，探讨影响这种早期边缘骨吸收的原因，以期对临床有指导意义。方法采用病例对照研究，选取44例种植患者，根据有无早期边缘骨吸收分为阳性组和阴性组；同时收集所有患者的颊黏膜拭子提取DNA；采用聚合酶链式反应对TNFA-308进行基因型的测定。结果TNFA-308基因型分布两组间差异无统计学意义；而吸烟分布在两组间差异有统计学意义（P=0.027）。经多元logistic回归分析，得出吸烟患者发生骨吸收是不吸烟患者的8.403倍（P〈0.05）。结论吸烟与早期边缘骨吸收发生有关，TNFA-308基因多态性不是边缘骨吸收发生的危险因素。

The Relationship between TNFA-308 Gene Polymorphism and Marginal Bone Loss Around Dental Implants

Objective The purpose is to evaluate the relationship between the genetic polymorphism of TNFA gene and the marginal bone loss around the implants before stage Ⅱ and to find the related factors influencing the marginal bone loss thus to predict the long stability of implants. Methods A ease-control study was used. Patients demonstrating marginal bone loss around implants at stage-Ⅱ surgery were designated as the inarginal bone loss （＋） ＇group and those without bone loss as the inarginal bone loss （-）＇group. Genomic DNA from buceal mueosa was amplified by the poly-merase chain reaction （PCR） to detect TNFA Gene. Results There were significant differences in the distributions of smoking between the two groups. However, the distribution of the TNFA-308 genotype was not significant in both groups. Multiple logistic regression shows the patients smoking had a 8.403 times greater likelihood of marginal bone loss than those without smoking. The differences between the other risk factors were non-significant. Conclusion Smoking is associated with early marginal bone loss and the TNFA-308 genotype in individual is not the risking factor of early marginal bone loss.