常用抗厌氧菌药物对牙龈卟啉单胞菌的体外抗菌活性研究

目的 研究口腔临床常用抗菌药物对牙周炎主要病原菌牙龈卟啉单胞菌（Pg)的抗菌活性。方法 用从成人牙周炎患者龈下菌斑中分离的、通过PCR鉴定的106株Pg临床分离株,采用琼脂稀释法测定了甲硝唑、克林霉素和替硝唑对三种不同浓度Pg菌液的最小抑菌浓度（MIC）。结果 上述药物对Pg的MIC范围依次是≤0.25-8mg/L,≤0.06-8mg/L和≤0.06-4mg/L,MIC90依次为8mg/L,8mg/L,4mg/L.10^5CPU/ml,10^6CFU/ml和10^8CPU/ml三种菌液浓度对实验结果无明显影响。结论 Pg对这三种药都非常敏感,敏感性大小依次为替硝唑、克林霉素和甲硝唑。

Antibacterial activities of some commonly used antibiotics to 106 isolated strains of porphyromonas ginginalis in vitro

Objective Porphyromonas gingivalis(Pg)is one of the main putative pathogens of periodontal disease,espcially of adult periodontitis.This in vitro study was aimed at observing the inhibition actions of 3 kinds of antimicrobial drugs on Pg.Methods 106 stains of Pg were isolated from subgingival plaques with adult periodontitis.The agar diffusion test was used to detect the inhibition actions of metronidazole,clindamycin and tinidazole on 106 stains of Pg.Results Their MIC was respectively:0.25mg/L,0.6mg/L.The MIC 90 of tinidazole