| 麻黄汤不同配伍对大鼠发汗作用的定量评价 |
| |
| 引用本文： | 熊倩,张密,郑青山.麻黄汤不同配伍对大鼠发汗作用的定量评价[J].中国临床药理学与治疗学,2011,27(7):763-768. |
| |
| 作者姓名： | 熊倩 张密 郑青山 |
| |
| 作者单位： | 上海中医药大学药物临床研究中心,上海,201203 |
| |
| 摘 要： | 目的:基于麻黄汤不同配伍对大鼠发汗影响的实验数据,采用模型化与模拟化方法进行再分析,提取更多信息,阐明其配伍规律,为优化组方提供参考。方法:麻黄汤4个组分为L14(24+)正交设计,1水平为"使用",0水平为"不使用",药效指标为大鼠腋窝皮肤汗腺空泡发生率为作用指数。采用正交模拟法与非线性混合效应模型(NONMEM),分析各组分在复方背景下的重要程度和相互作用。模拟偏倚由4种视图及单组分实验结果综合评价。结果:麻黄汤各组分对大鼠发汗作用的药效影响按重要程度排序依次是桂枝(B)、麻黄(A)、杏仁(C)和甘草(D),药效最佳组合为麻黄+桂枝,最弱组合为杏仁+甘草。结论:麻黄汤发汗作用药效贡献最大的为麻黄、桂枝,且两者作用相当,发挥最佳发汗作用须两者联用。
|
| 关 键 词： | 麻黄汤 配伍 模拟 定量分析 |
Quantitative evaluation of pharmacodynamic interactions on diaphoretic effects among the components of Mao-to in rats |
| |
| XIONG Qian,ZHANG Mi,ZHENG Qing-shan.Quantitative evaluation of pharmacodynamic interactions on diaphoretic effects among the components of Mao-to in rats[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,27(7):763-768. |
| |
| Authors: | XIONG Qian ZHANG Mi ZHENG Qing-shan |
| |
| Institution: | XIONG Qian,ZHANG Mi,ZHENG Qing-shan Center for Drug of Clinical Research,Shanghai University of Chinese Medicine,Shanghai 201203,China |
| |
| Abstract: | AIM: To analyze pharmacodynamic interaction on diaphoretic effects among the components from Mao-to for finding an optimal combination. METHODS: According to the four components that included in Mao-to,an orthogonal design with 1-level = used and 0-level = not used,was selected in L14(24) and a mathematical model was built up with the nonlinear mixed effect model(NONMEM) for rat experiment.Vacuole incidence of axillary sweat gland was determined to evaluate the diaphoretic effect.The importance and effectiv... |
| |
| Keywords: | Mao-to Compound Simulation Pharmacodynamic interactions |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
