| 丹酚酸B镁盐对自由基的清除作用和对脂质过氧化的抑制作用(英文) |
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| 引用本文： | Wu XJ,Wang YP,Wang W,Sun WK,Xu YM,Xuan LJ. 丹酚酸B镁盐对自由基的清除作用和对脂质过氧化的抑制作用(英文)[J]. Acta pharmacologica Sinica, 2000, 21(9): 855-858 |
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| 作者姓名： | Wu XJ Wang YP Wang W Sun WK Xu YM Xuan LJ |
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| 摘 要： |
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| 关 键 词： | 丹参 丹酚酸B镁盐 羟自由基 超氧化物 脂质过氧化 |
Free radical scavenging and inhibition of lipid peroxidation by magnesium lithospermate B |
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| Wu X J,Wang Y P,Wang W,Sun W K,Xu Y M,Xuan L J. Free radical scavenging and inhibition of lipid peroxidation by magnesium lithospermate B[J]. Acta pharmacologica Sinica, 2000, 21(9): 855-858 |
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| Authors: | Wu X J Wang Y P Wang W Sun W K Xu Y M Xuan L J |
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| Affiliation: | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China. |
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| Abstract: | AIM: To study the effect of magnesium lithospermate B (MLB) on the lipid peroxidation and on its free radical scavenging activity. METHODS: MLB was incubated in rat tissue homogenate or in a free radical generating system. MLB induced inhibition of lipid peroxidation and its scavenging activity on superoxide anions and hydroxyl radicals was studied using colorimetric estimation. RESULTS: MLB inhibited the lipid peroxidation induced by either an auto-oxidant or Fe2+/VitC in vitro, in the liver homogenate, the inhibitory rate of MLB (10 mg/L) being 69.2% and 57.7%, respectively. MLB (25 and 50 mg/kg) decreased the amount of thiobarbituric acid reactive substances (TBARS) in rat serum, liver, kidney, and heart. However, it did not inhibit the lipid peroxidation of brain homogenate ex vivo. MLB scavenged superoxide anions generated from xanthine/xanthine oxidase system and iron-dependent hydroxyl radicals. CONCLUSION: MLB is an inhibitor of lipid peroxidation and scavenge superoxide anions and hydroxyl radicals both in vitro and ex vivo. |
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| Keywords: | Salvia miltiorrhiza magnesium lithos-permate B hydroxyl radical superoxides lipid peroxi-dation |
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