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| 乙醇心血管保护作用的潜在机制(英文) | |
| 引用本文： | Redmond EM,Sitzmann JV,Cahill PA. 乙醇心血管保护作用的潜在机制(英文)[J]. Acta pharmacologica Sinica, 2000, 21(5): 385-390 |
| 作者姓名： | Redmond EM Sitzmann JV Cahill PA |
| 作者单位： | Department of Surgery,University of Rochester Medical Center,Box SURG,601 Elmwood Avenue,Rochester NY 14642-8410,USA |
| 摘 要： | Epidemiological studies demonstrate a significant protective effect of moderate alcohol consumption on the incidence of cardiovascular diseases which accounts for the majority of deaths in the Western world. In this review, possible mechanisms to explain the cardioprotective effect of ethanol are discussed. While the prevailing theory supported by a number of clinical and animal studies indicates that the ability of ethanol to elevate serum high-density lipoprotein (HDL) cholesterol levels is an important mechanism in ameliorating cardiovascular disease, other mechanisms whereby ethanol could exert its beneficial effect have been proposed. Namely, its ability to affect platelet function and endothelial cell and vascular smooth muscle cell function (In this review, the terms alcohol and ethanol are used interchangeably). |
| 关 键 词： | 醇类 血管平滑肌 内皮 动脉粥样硬化 |
Potential mechanisms for cardiovascular protective effect of ethanol |
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| Redmond E M,Sitzmann J V,Cahill P A. Potential mechanisms for cardiovascular protective effect of ethanol[J]. Acta pharmacologica Sinica, 2000, 21(5): 385-390 | |
| Authors: | Redmond E M Sitzmann J V Cahill P A |
| Affiliation: | Department of Surgery, University of Rochester Medical Center, Box SURG, 601 Elmwood Avenue, Rochester, NY 14642-8410, USA. eileen_redmond@urmc.rochester.edu |
| Abstract: | Epidemiological studies demonstrate a significant protective effect of moderate alcohol consumption on the incidence of cardiovascular diseases which accounts for the majority of deaths in the Western world. In this review, possible mechanisms to explain the cardioprotective effect of ethanol are discussed. While the prevailing theory supported by a number of clinical and animal studies indicates that the ability of ethanol to elevate serum high-density lipoprotein (HDL) cholesterol levels is an important mechanism in ameliorating cardiovascular disease, other mechanisms whereby ethanol could exert its beneficial effect have been proposed. Namely, its ability to affect platelet function and endothelial cell and vascular smooth muscle cell function (In this review, the terms alcohol and ethanol are used interchangeably). |
| Keywords: | alcohols vascular smooth muscle endothelium atherosclerosis |
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