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| 中国人群中CYP1A2基因G-2964A和C734A多态性分布 | |
| 引用本文： | Han XM,Chen XP,Wu QN,Jiang CH,Zhou HH. 中国人群中CYP1A2基因G-2964A和C734A多态性分布[J]. Acta pharmacologica Sinica, 2000, 21(11): 1031-1034 |
| 作者姓名： | Han XM Chen XP Wu QN Jiang CH Zhou HH |
| 作者单位： | 湖南医科大学基础与临床药理研究所遗传药理研究室,湖南医科大学基础与临床药理研究所遗传药理研究室,启东肝癌研究所,湖南医科大学基础与临床药理研究所遗传药理研究室 长沙 410078 中国,长沙 410078 中国,启东 226200 中国,长沙 410078 中国 |
| 基金项目： | Project supported by the National Natural Science Foundation of China, No F39330230,by China Medical Board of New York grants 92-568 and 99-697. |
| 摘 要： | 目的:研究中国人群中CYPlA2基因G-2964A和C734A多态性分布.方法:应用聚合酶链反应-限制片长多态性技术对163名启东人和78名长沙人进行基因型分析.结果:等位基因A-2964在启东和长沙人中的发生率分别是0.25和0.22.A734的发生率在启东人中为0.68,而在长沙人中为0.66.一个受试者的两条等位基因中至多含有两个底活性位点.结论:G-2964A和C734A基因多态性在中国人和日本人中的分布没有显著性差异,C734A基因多态性在中国人中的分布也类似于白种人. |
| 关 键 词： | 细胞色素P-450 CYPlA2 聚合酶链反应 基因型 限制片长多态性 中国人 |
G-2964A and C734A genetic polymorphisms of CYP1A2 in Chinese population |
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| Han X M,Chen X P,Wu Q N,Jiang C H,Zhou H H. G-2964A and C734A genetic polymorphisms of CYP1A2 in Chinese population[J]. Acta pharmacologica Sinica, 2000, 21(11): 1031-1034 | |
| Authors: | Han X M Chen X P Wu Q N Jiang C H Zhou H H |
| Affiliation: | Pharmacogenetics Research Institute, Basic and Clinical Pharmacology Institute, Hunan Medical University, Changsha 410078, China. |
| Abstract: | AIM: To observe the G-2964A and C734A genetic polymorphisms of human CYP1A2 in Chinese population. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed in genotyping analysis. RESULTS: The allele frequencies of A-2964 were 0.25 and 0.22 in Qidong and Changsha populations, respectively. The incidences of A734 were 0.68 in Qidong population and 0.66 in Changsha population. No more than two low-inducibili-ty/activity alleles were presented in one person. CONCLUSION: The distribution of the G-2964A and C734A genetic polymorphisms did not show significant difference between Chinese and Japanese populations. The incidence of C734A in Chinese was also similar to that in Caucasian population. |
| Keywords: | cytochrome P-450 CYP1A2 poly-merase chain reaction genotype restriction fragment length polymorphism Chinese |
| 本文献已被 CNKI PubMed 等数据库收录！ | |